The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Albert van Dijk, Chris Juul Hedegaard, Henk P. Haagsman*, Peter Mikael Helweg Heegaard

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation. As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense. First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
    Original languageEnglish
    Article number68
    JournalVeterinary Research
    Volume49
    Number of pages15
    ISSN0928-4249
    DOIs
    Publication statusPublished - 2018

    Bibliographical note

    This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creat iveco mmons .org/publi cdoma in/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

    Keywords

    • VETERINARY
    • INTESTINAL EPITHELIAL-CELLS
    • HUMAN DENDRITIC CELLS
    • BETA-DEFENSIN
    • HUMAN CATHELICIDIN
    • ESCHERICHIA-COLI
    • IMMUNE-RESPONSES
    • ANTIMICROBIAL ACTIVITY
    • INFECTIOUS-DISEASES
    • HUMAN BETA-DEFENSIN-2
    • BACTERIAL-INFECTIONS

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