The porcine acute phase response to infection with Actinobacillus pleuropneumoniae. Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid a protein are sensitive indicators of infection

Peter M. H. Heegaard, Joan Klausen, J.P. Nielsen, N. Gonzalez-Ramon, M. Pineiro, F. Lampreave, M.A. Alava

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    In an experimental infection model mimicking acute Actinobacillus pleuropneumoniae (Ap) infection in swine (Sus scrofa) by aerosol inoculation, the development of a number of typical clinical signs was accompanied by a prototypic acute phase reaction encompassing fever and an acute phase protein response peaking at around 2 days after infection. Haptoglobin, C-reactive protein (CRP), and major acute phase protein (MAP) responded with large increases in serum levels, preceding the development of specific antibodies by 4-5 days. Serum amyloid A protein (SAA) was also strongly induced. The increase, kinetics of induction and normalization were different between these proteins. It is concluded that experimental Ap-infection by the aerosol route induces a typical acute phase reaction in the pig, and that pig Hp, CRP, MAP, and SAA are major acute phase reactants. These findings indicate the possibility of using one or more of these reactants for the nonspecific surveillance of pig health status.
    Original languageEnglish
    JournalComparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
    Volume119
    Issue number2
    Pages (from-to)365-373
    ISSN1096-4959
    DOIs
    Publication statusPublished - 1998

    Keywords

    • Actinobacillus pleuropneumoniae infection
    • acute phase reaction
    • haptoglobin
    • major acute phase protein (MAP)
    • serum amyloid A protein (SAA)
    • C-reactive protein (CRP)
    • pig

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