TY - JOUR
T1 - The porcine acute phase response to infection with Actinobacillus pleuropneumoniae. Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid a protein are sensitive indicators of infection
AU - Heegaard, Peter M. H.
AU - Klausen, Joan
AU - Nielsen, J.P.
AU - Gonzalez-Ramon, N.
AU - Pineiro, M.
AU - Lampreave, F.
AU - Alava, M.A.
PY - 1998
Y1 - 1998
N2 - In an experimental infection model mimicking acute Actinobacillus pleuropneumoniae (Ap) infection in swine (Sus scrofa) by aerosol inoculation, the development of a number of typical clinical signs was accompanied by a prototypic acute phase reaction encompassing fever and an acute phase protein response peaking at around 2 days after infection. Haptoglobin, C-reactive protein (CRP), and major acute phase protein (MAP) responded with large increases in serum levels, preceding the development of specific antibodies by 4-5 days. Serum amyloid A protein (SAA) was also strongly induced. The increase, kinetics of induction and normalization were different between these proteins. It is concluded that experimental Ap-infection by the aerosol route induces a typical acute phase reaction in the pig, and that pig Hp, CRP, MAP, and SAA are major acute phase reactants. These findings indicate the possibility of using one or more of these reactants for the nonspecific surveillance of pig health status.
AB - In an experimental infection model mimicking acute Actinobacillus pleuropneumoniae (Ap) infection in swine (Sus scrofa) by aerosol inoculation, the development of a number of typical clinical signs was accompanied by a prototypic acute phase reaction encompassing fever and an acute phase protein response peaking at around 2 days after infection. Haptoglobin, C-reactive protein (CRP), and major acute phase protein (MAP) responded with large increases in serum levels, preceding the development of specific antibodies by 4-5 days. Serum amyloid A protein (SAA) was also strongly induced. The increase, kinetics of induction and normalization were different between these proteins. It is concluded that experimental Ap-infection by the aerosol route induces a typical acute phase reaction in the pig, and that pig Hp, CRP, MAP, and SAA are major acute phase reactants. These findings indicate the possibility of using one or more of these reactants for the nonspecific surveillance of pig health status.
KW - Actinobacillus pleuropneumoniae infection
KW - acute phase reaction
KW - haptoglobin
KW - major acute phase protein (MAP)
KW - serum amyloid A protein (SAA)
KW - C-reactive protein (CRP)
KW - pig
U2 - 10.1016/S0305-0491(97)00362-3
DO - 10.1016/S0305-0491(97)00362-3
M3 - Journal article
SN - 1096-4959
VL - 119
SP - 365
EP - 373
JO - Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
JF - Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
IS - 2
ER -