The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform

Research output: Contribution to journalJournal article – Annual report year: 2017Researchpeer-review

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  • Author: Schachtschneider, Kyle M.

    University of Illinois at Chicago, United States

  • Author: Schwind, Regina M.

    University of Illinois at Chicago, United States

  • Author: Newson, Jordan

    Albion College, United States

  • Author: Kinachtchouk, Nickolas

    Albion College, United States

  • Author: Rizko, Mark

    University of Illinois at Chicago, United States

  • Author: Mendoza-Elias, Nasya

    University of Illinois at Chicago, United States

  • Author: Grippo, Paul

    University of Illinois at Chicago, United States

  • Author: Principe, Daniel R.

    University of Illinois at Chicago, United States

  • Author: Park, Alex

    University of Illinois at Chicago, United States

  • Author: Overgaard, Nana Haahr

    T-cells & Cancer, Adaptive Immunology, Division of Immunology & Vaccinology, National Veterinary Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Jungersen, Gregers

    Adaptive Immunology, Division of Immunology & Vaccinology, National Veterinary Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Garcia, Kelly D.

    University of Illinois at Chicago, United States

  • Author: Maker, Ajay V.

    University of Illinois at Chicago, United States

  • Author: Rund, Laurie A.

    University of Illinois, United States

  • Author: Ozer, Howard

    University of Illinois at Chicago, United States

  • Author: Gaba, Ron C.

    University of Illinois at Chicago, United States

  • Author: Schook, Lawrence B.

    University of Illinois at Chicago, United States

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Despite an improved understanding of cancer molecular biology, immune landscapes, and advancements in cytotoxic, biologic, and immunologic anti-cancer therapeutics, cancer remains a leading cause of death worldwide. More than 8.2 million deaths were attributed to cancer in 2012, and it is anticipated that cancer incidence will continue to rise, with 19.3 million cases expected by 2025. The development and investigation of new diagnostic modalities and innovative therapeutic tools is critical for reducing the global cancer burden. Toward this end, transitional animal models serve a crucial role in bridging the gap between fundamental diagnostic and therapeutic discoveries and human clinical trials. Such animal models offer insights into all aspects of the basic science-clinical translational cancer research continuum (screening, detection, oncogenesis, tumor biology, immunogenicity, therapeutics, and outcomes). To date, however, cancer research progress has been markedly hampered by lack of a genotypically, anatomically, and physiologically relevant large animal model. Without progressive cancer models, discoveries are hindered and cures are improbable. Herein, we describe a transgenic porcine model-the Oncopig Cancer Model (OCM)-as a next-generation large animal platform for the study of hematologic and solid tumor oncology. With mutations in key tumor suppressor and oncogenes, TP53R167H and KRASG12D , the OCM recapitulates transcriptional hallmarks of human disease while also exhibiting clinically relevant histologic and genotypic tumor phenotypes. Moreover, as obesity rates increase across the global population, cancer patients commonly present clinically with multiple comorbid conditions. Due to the effects of these comorbidities on patient management, therapeutic strategies, and clinical outcomes, an ideal animal model should develop cancer on the background of representative comorbid conditions (tumor macro- and microenvironments). As observed in clinical practice, liver cirrhosis frequently precedes development of primary liver cancer or hepatocellular carcinoma. The OCM has the capacity to develop tumors in combination with such relevant comorbidities. Furthermore, studies on the tumor microenvironment demonstrate similarities between OCM and human cancer genomic landscapes. This review highlights the potential of this and other large animal platforms as transitional models to bridge the gap between basic research and clinical practice.
Original languageEnglish
Article number190
JournalFrontiers in Oncology
Volume7
DOIs
Publication statusPublished - 2017

Bibliographical note

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Cancer models, Clinical needs, Oncology, Oncopig, Pigs, Translational medicine

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