The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations

Research output: Contribution to journalJournal article – Annual report year: 2011Researchpeer-review

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The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. / Vogel, Ulla Birgitte; Jensen, Majken K.; Due, Karen Margrete; Rimm, Eric B.; Wallin, Håkan; Nielsen, Michael R.S.; Pedersen, Anne-Pernille T.; Tjønneland, Anne; Overvad, Kim.

In: Atherosclerosis, Vol. 219, No. 1, 2011, p. 200-204.

Research output: Contribution to journalJournal article – Annual report year: 2011Researchpeer-review

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Vogel, UB, Jensen, MK, Due, KM, Rimm, EB, Wallin, H, Nielsen, MRS, Pedersen, A-PT, Tjønneland, A & Overvad, K 2011, 'The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations', Atherosclerosis, vol. 219, no. 1, pp. 200-204. https://doi.org/10.1016/j.atherosclerosis.2011.06.018

APA

CBE

Vogel UB, Jensen MK, Due KM, Rimm EB, Wallin H, Nielsen MRS, Pedersen A-PT, Tjønneland A, Overvad K. 2011. The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. Atherosclerosis. 219(1):200-204. https://doi.org/10.1016/j.atherosclerosis.2011.06.018

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Vogel, Ulla Birgitte ; Jensen, Majken K. ; Due, Karen Margrete ; Rimm, Eric B. ; Wallin, Håkan ; Nielsen, Michael R.S. ; Pedersen, Anne-Pernille T. ; Tjønneland, Anne ; Overvad, Kim. / The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. In: Atherosclerosis. 2011 ; Vol. 219, No. 1. pp. 200-204.

Bibtex

@article{abc0417f1afc4a75a04367b0110ac733,
title = "The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations",
abstract = "AimInflammation is a risk factor for coronary heart disease (CHD). A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects. We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women. Methods and resultsThe NFKB1 ins/del polymorphism was genotyped in studies of CHD nested within the Diet, Cancer and Health (DCH) study, the Health Professionals Follow-up (HPFS) and the Nurses’ Health (NHS) studies, totaling 1008, 428 and 439 cases, respectively. The minor allele frequency in the combined sample was 0.38 among controls. In a pooled analysis, the relative risk (RR) among heterozygous men and women was 1.22 (95{\%} CI: 1.07–1.40), compared to the most common ins/ins genotype. The RR among homozygotes was 1.20 (95{\%} CI: 0.94–1.53). There was no evidence of an allele-dosage effect, and in a dominant model the RR among del-allele carriers was 1.22 (95{\%} CI: 1.07–1.39). The risk was similar in women and men (RR was 1.20 in women and 1.23 in men, respectively). The NFKB1 variant was not associated with plasma lipid levels, but del-carriers had lower levels of C-reactive protein. ConclusionsThe NFKB1 promoter variant, previously shown to cause partial depletion of NF-κB p50, was associated with a higher risk of CHD in three independent prospective studies of generally healthy Caucasians.",
keywords = "Polymorphism, NF-kB, Population-based, Inflammation",
author = "Vogel, {Ulla Birgitte} and Jensen, {Majken K.} and Due, {Karen Margrete} and Rimm, {Eric B.} and H{\aa}kan Wallin and Nielsen, {Michael R.S.} and Pedersen, {Anne-Pernille T.} and Anne Tj{\o}nneland and Kim Overvad",
year = "2011",
doi = "10.1016/j.atherosclerosis.2011.06.018",
language = "English",
volume = "219",
pages = "200--204",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations

AU - Vogel, Ulla Birgitte

AU - Jensen, Majken K.

AU - Due, Karen Margrete

AU - Rimm, Eric B.

AU - Wallin, Håkan

AU - Nielsen, Michael R.S.

AU - Pedersen, Anne-Pernille T.

AU - Tjønneland, Anne

AU - Overvad, Kim

PY - 2011

Y1 - 2011

N2 - AimInflammation is a risk factor for coronary heart disease (CHD). A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects. We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women. Methods and resultsThe NFKB1 ins/del polymorphism was genotyped in studies of CHD nested within the Diet, Cancer and Health (DCH) study, the Health Professionals Follow-up (HPFS) and the Nurses’ Health (NHS) studies, totaling 1008, 428 and 439 cases, respectively. The minor allele frequency in the combined sample was 0.38 among controls. In a pooled analysis, the relative risk (RR) among heterozygous men and women was 1.22 (95% CI: 1.07–1.40), compared to the most common ins/ins genotype. The RR among homozygotes was 1.20 (95% CI: 0.94–1.53). There was no evidence of an allele-dosage effect, and in a dominant model the RR among del-allele carriers was 1.22 (95% CI: 1.07–1.39). The risk was similar in women and men (RR was 1.20 in women and 1.23 in men, respectively). The NFKB1 variant was not associated with plasma lipid levels, but del-carriers had lower levels of C-reactive protein. ConclusionsThe NFKB1 promoter variant, previously shown to cause partial depletion of NF-κB p50, was associated with a higher risk of CHD in three independent prospective studies of generally healthy Caucasians.

AB - AimInflammation is a risk factor for coronary heart disease (CHD). A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects. We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women. Methods and resultsThe NFKB1 ins/del polymorphism was genotyped in studies of CHD nested within the Diet, Cancer and Health (DCH) study, the Health Professionals Follow-up (HPFS) and the Nurses’ Health (NHS) studies, totaling 1008, 428 and 439 cases, respectively. The minor allele frequency in the combined sample was 0.38 among controls. In a pooled analysis, the relative risk (RR) among heterozygous men and women was 1.22 (95% CI: 1.07–1.40), compared to the most common ins/ins genotype. The RR among homozygotes was 1.20 (95% CI: 0.94–1.53). There was no evidence of an allele-dosage effect, and in a dominant model the RR among del-allele carriers was 1.22 (95% CI: 1.07–1.39). The risk was similar in women and men (RR was 1.20 in women and 1.23 in men, respectively). The NFKB1 variant was not associated with plasma lipid levels, but del-carriers had lower levels of C-reactive protein. ConclusionsThe NFKB1 promoter variant, previously shown to cause partial depletion of NF-κB p50, was associated with a higher risk of CHD in three independent prospective studies of generally healthy Caucasians.

KW - Polymorphism

KW - NF-kB

KW - Population-based

KW - Inflammation

U2 - 10.1016/j.atherosclerosis.2011.06.018

DO - 10.1016/j.atherosclerosis.2011.06.018

M3 - Journal article

VL - 219

SP - 200

EP - 204

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -