The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

F.M. Campbell; M. Waterston; Lars Ole Andresen; Nanna Skall Sørensen; Peter M. H. Heegaard; P.D. Eckersall

doi:10.1051/vetres:2005017

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

F.M. Campbell, M. Waterston, Lars Ole Andresen, Nanna Skall Sørensen, Peter M. H. Heegaard, P.D. Eckersall

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

Original language	English
Journal	Veterinary Research
Volume	36
Issue number	4
Pages (from-to)	657-664
ISSN	0928-4249
DOIs	https://doi.org/10.1051/vetres:2005017
Publication status	Published - 2005

Keywords

infection Streptococcus suis
pigs
acute phase proteins

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1051/vetres:2005017

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title = "The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig",

abstract = "Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.",

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T1 - The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

AU - Campbell, F.M.

AU - Waterston, M.

AU - Andresen, Lars Ole

AU - Sørensen, Nanna Skall

AU - Heegaard, Peter M. H.

AU - Eckersall, P.D.

PY - 2005

Y1 - 2005

N2 - Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

AB - Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

KW - infection Streptococcus suis

KW - pigs

KW - acute phase proteins

U2 - 10.1051/vetres:2005017

DO - 10.1051/vetres:2005017

M3 - Journal article

SN - 0928-4249

VL - 36

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JO - Veterinary Research

JF - Veterinary Research

IS - 4

ER -

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

Abstract

Keywords

UN SDGs

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