The met axial ligand determines the redox potential in Cu-A sites

G.N. Ledesma, D.H. Murgida, H.K. Ly, Hainer Wackerbarth, Jens Ulstrup, A.J. Costa, A.J. Vila

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The replacement of the axial methionine ligand in a native Cu-A protein rendered a series of stable mutants with spectroscopic features of a mixed valence center. The mutations resulted in minor perturbations of the electronic structure of this site but led to significant changes in the redox potential. This suggests that the axial ligand plays a role in tuning the redox potential Of Cu-A, resembling the behavior observed in blue copper sites.
Original languageEnglish
JournalJournal of the American Chemical Society
Volume129
Issue number39
Pages (from-to)11884
ISSN0002-7863
Publication statusPublished - 2007

Cite this

Ledesma, G. N., Murgida, D. H., Ly, H. K., Wackerbarth, H., Ulstrup, J., Costa, A. J., & Vila, A. J. (2007). The met axial ligand determines the redox potential in Cu-A sites. Journal of the American Chemical Society, 129(39), 11884.