The landscape of existing models for high-throughput exposure assessment

O. Jolliet, Peter Fantke, L. Huang

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    Models are becoming increasingly available to model near-field fate and exposure, but not all are suited for high throughput. This presentation evaluates the available models for modeling exposure to chemicals in cosmetics, cleaning products, food contact and building materials. It assesses their applicability to quantitative high throughput exposure assessment in CAA and CRA, looking in particular at the following characteristics: validity of main assumptions; availability of analytical solutions and model parsimony; availability of methods to estimate key inputs for a large number of chemicals and ability to easily handle large datasets. For building materials a series of diffusion-based models have been developed to predict the chemicals emissions from building materials to indoor air, but existing models require complex analytical or numerical solutions, which are not suitable for LCA or HTS applications. Thus, existing model solutions needed to be simplified for application in LCA and HTS, and a parsimonious model has been developed by Huang et al. (2017) to address this need. For SVOCs, simplified solutions do exist, assuming constant SVOC concentrations in building materials and steadystate in indoor air (Little et al., 2012; Liu et al., 2013), but they do not well account for SVOC sorption into indoor surfaces and absorption into human skins (Huang et al., 2017). Thus a more comprehensive simplified solution is needed for SVOCs . For personal Care Products, a mass balance model that accounts for skin permeation and volatilization as competing processes and that requires a limited number of readily available physiochemical properties would be suitable for LCA and HTS purposes. Thus, the multi-pathway exposure model for chemicals in cosmetics developed by Ernstoff et al.constitutes a suitable basis and can be refined in the future. The review will also address models available for modeling chemicals in cleaning products and other indoor used chemicals.
    Original languageEnglish
    Title of host publicationAbstract book - ISES 27th Annual Meeting
    Publication date2017
    Article numberMO-SY-F3-148
    Publication statusPublished - 2017
    Event27th Annual meeting of the International Society of Exposure Science - Research Triangle Park, United States
    Duration: 15 Oct 201719 Oct 2017
    Conference number: 27


    Conference27th Annual meeting of the International Society of Exposure Science
    CountryUnited States
    CityResearch Triangle Park


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