TY - JOUR
T1 - The Incidence of Necrotizing Enterocolitis Is Increased Following Probiotic Administration to Preterm Pigs
AU - Cilieborg, Malene Skovsted
AU - Thymann, Thomas
AU - Siggers, Richard
AU - Boye, Mette
AU - Bering, Stine B.
AU - Jensen, Bent B.
AU - Sangild, Per T.
PY - 2011
Y1 - 2011
N2 - Preterm birth and necrotizing enterocolitis (NEC) is associated with inappropriate gut colonization and immunity, which may be improved by probiotic bacteria. Using a preterm pig model of NEC, we investigated the effects of probiotics on intestinal structure, function, microbiology, and immunology in the immediate postnatal period. Just after birth, caesarean-delivered preterm pigs were inoculated with Lactobacillus paracasei, Bifidobacteria animalis, and Streptococcus thermophilus (total 2.4 x 1010/d) either as live (ProLive, n = 14) or gamma-irradiated dead bacteria (ProDead, n = 12) and compared with controls (n = 14). All pigs received parenteral nutrition for 2 d followed by enteral formula feeding until tissue collection on d 5. Compared with control pigs, intestinal weight was lower and NEC incidence was higher in both groups given probiotics (64–67 vs. 14%; P
AB - Preterm birth and necrotizing enterocolitis (NEC) is associated with inappropriate gut colonization and immunity, which may be improved by probiotic bacteria. Using a preterm pig model of NEC, we investigated the effects of probiotics on intestinal structure, function, microbiology, and immunology in the immediate postnatal period. Just after birth, caesarean-delivered preterm pigs were inoculated with Lactobacillus paracasei, Bifidobacteria animalis, and Streptococcus thermophilus (total 2.4 x 1010/d) either as live (ProLive, n = 14) or gamma-irradiated dead bacteria (ProDead, n = 12) and compared with controls (n = 14). All pigs received parenteral nutrition for 2 d followed by enteral formula feeding until tissue collection on d 5. Compared with control pigs, intestinal weight was lower and NEC incidence was higher in both groups given probiotics (64–67 vs. 14%; P
U2 - 10.3945/jn.110.128561
DO - 10.3945/jn.110.128561
M3 - Journal article
SN - 0022-3166
VL - 141
SP - 223
EP - 230
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 2
ER -