The Importance of Magnesium in the Human Body: A Systematic Literature Review

Sidsel-Marie Glasdam, Stinne Glasdam, Günther H.J. Peters

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Magnesium, the second and fourth most abundant cation in the intracellular compartment and whole body, respectively, is of great physiologic importance. Magnesium exists as bound and free ionized forms depending on temperature, pH, ionic strength, and competing ions. Free magnesium participates in many biochemical processes and is most commonly measured by ion-selective electrode. This analytical approach is problematic because complete selectivity is not possible due to competition with other ions, i.e., calcium, and pH interference. Unfortunately, many studies have focused on measurement of total magnesium rather than its free bioactive form making it difficult to correlate to disease states. This systematic literature review presents current analytical challenges in obtaining accurate and reproducible test results for magnesium.
Original languageEnglish
Title of host publication Advances in Clinical Chemistry
PublisherElsevier
Publication date2016
Pages169–193
DOIs
Publication statusPublished - 2016
SeriesAdvances in Clinical Chemistry
Volume73
ISSN0065-2423

Keywords

  • Analytical methods
  • Biologic function
  • Blood
  • Electrolytes
  • Interference
  • Magnesium

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