The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens - a study in Brown Norway rats.

Jeanette Lund Madsen, Stine Kroghsbo, Charlotte Bernhard Madsen, Irina Pozdnyakova, Vibeke Barkholt, Katrine Lindholm Bøgh

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Abstract

This study showed that the three-dimensional (3D) structure has a significant impact on the antibodies raised for both systemic and orally administered allergens. A remarkable difference in the antibody binding patterns against linear and conformational epitope was seen between the allergens, indicating that the structural characteristics of proteins may heavily affect the induced antibody response.
Original languageEnglish
Article number25
JournalClinical and Translational Allergy
Volume4
Issue number1
Number of pages11
ISSN2045-7022
DOIs
Publication statusPublished - 2014

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