The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens - a study in Brown Norway rats.

Jeanette Lund Madsen, Stine Kroghsbo, Charlotte Bernhard Madsen, Irina Pozdnyakova, Vibeke Barkholt, Katrine Lindholm Bøgh

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Abstract

This study showed that the three-dimensional (3D) structure has a significant impact on the antibodies raised for both systemic and orally administered allergens. A remarkable difference in the antibody binding patterns against linear and conformational epitope was seen between the allergens, indicating that the structural characteristics of proteins may heavily affect the induced antibody response.
Original languageEnglish
Article number25
JournalClinical and Translational Allergy
Volume4
Issue number1
Number of pages11
ISSN2045-7022
DOIs
Publication statusPublished - 2014

Cite this

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title = "The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens - a study in Brown Norway rats.",
abstract = "This study showed that the three-dimensional (3D) structure has a significant impact on the antibodies raised for both systemic and orally administered allergens. A remarkable difference in the antibody binding patterns against linear and conformational epitope was seen between the allergens, indicating that the structural characteristics of proteins may heavily affect the induced antibody response.",
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language = "English",
volume = "4",
journal = "Clinical and Translational Allergy",
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publisher = "BioMed Central Ltd.",
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The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens - a study in Brown Norway rats. / Madsen, Jeanette Lund; Kroghsbo, Stine; Madsen, Charlotte Bernhard; Pozdnyakova, Irina; Barkholt, Vibeke; Bøgh, Katrine Lindholm.

In: Clinical and Translational Allergy, Vol. 4, No. 1, 25, 2014.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens - a study in Brown Norway rats.

AU - Madsen, Jeanette Lund

AU - Kroghsbo, Stine

AU - Madsen, Charlotte Bernhard

AU - Pozdnyakova, Irina

AU - Barkholt, Vibeke

AU - Bøgh, Katrine Lindholm

PY - 2014

Y1 - 2014

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AB - This study showed that the three-dimensional (3D) structure has a significant impact on the antibodies raised for both systemic and orally administered allergens. A remarkable difference in the antibody binding patterns against linear and conformational epitope was seen between the allergens, indicating that the structural characteristics of proteins may heavily affect the induced antibody response.

U2 - 10.1186/2045-7022-4-25

DO - 10.1186/2045-7022-4-25

M3 - Journal article

VL - 4

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

SN - 2045-7022

IS - 1

M1 - 25

ER -