The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

Mariam Andersson, Jonathan Rafael-Patino, Hans Martin Kjer, Vedrana Andersen Dahl, Alexandra Pacureanu, Martin Bech, Anders Bjorholm Dahl, Jean-Philippe Thiran, Tim Bjørn Dyrby

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.
Original languageEnglish
Title of host publicationProceedings of 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages3
PublisherThe International Society for Magnetic Resonance in Medicine
Publication date2020
Pages1-3
Publication statusPublished - 2020
Event2020 ISMRM & SMRT Virtual Conference & Exhibition - Online
Duration: 8 Aug 202014 Aug 2020

Conference

Conference2020 ISMRM & SMRT Virtual Conference & Exhibition
LocationOnline
Period08/08/202014/08/2020
SeriesProceedings of 2020 ISMRM & SMRT Virtual Conference & Exhibition

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