The human cell atlas

Aviv Regev; Sarah A. Teichmann; Eric S. Lander; Ido Amit; Christophe Benoist; Ewan Birney; Bernd Bodenmiller; Peter Campbell; Piero Carninci; Menna Clatworthy; Hans Clevers; Bart Deplancke; Ian Dunham; James Eberwine; Roland Eils; Wolfgang Enard; Andrew Farmer; Lars Fugger; Berthold Göttgens; Nir Hacohen; Muzlifah Haniffa; Martin Hemberg; Seung Kim; Paul Klenerman; Arnold Kriegstein; Ed Lein; Sten Linnarsson; Emma Lundberg; Joakim Lundeberg; Partha Majumder; John C. Marioni; Miriam Merad; Musa Mhlanga; Martijn Nawijn; Mihai Netea; Garry Nolan; Dana Pe’er; Anthony Phillipakis; Chris P. Ponting; Stephen Quake; Wolf Reik; Orit Rozenblatt-Rosen; Joshua Sanes; Rahul Satija; Ton N. Schumacher; Alex Shalek; Ehud Shapiro; Padmanee Sharma; Jay W. Shin; Mathias Uhlén; Human Cell Atlas Meeting Participants

doi:10.7554/eLife.27041

The human cell atlas

Aviv Regev^*
, Sarah A. Teichmann
, Eric S. Lander
, Ido Amit
, Christophe Benoist
, Ewan Birney
, Bernd Bodenmiller
, Peter Campbell
, Piero Carninci
, Menna Clatworthy
, Hans Clevers
, Bart Deplancke
, Ian Dunham
, James Eberwine
, Roland Eils
, Wolfgang Enard
, Andrew Farmer
, Lars Fugger
, Berthold Göttgens
, Nir Hacohen

Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C. Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe’er, Anthony Phillipakis, Chris P. Ponting, Stephen Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N. Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W. Shin, Mathias Uhlén, Human Cell Atlas Meeting Participants

^*Corresponding author for this work

University of Cambridge
Weizmann Institute of Science
University of Zurich
RIKEN
Swiss Federal Institute of Technology Lausanne
University of Pennsylvania
Heidelberg University
Ludwig Maximilian University of Munich
Takara Bio USA, Inc.
University of Oxford
Newcastle University
Stanford University
Oxford University Hospitals NHS Foundation Trust
Allen Institute for Brain Science
Karolinska Institutet
KTH Royal Institute of Technology
National Institute of Biomedical Genomics
Icahn School of Medicine at Mount Sinai
University of Cape Town
University of Groningen
Radboud University Nijmegen
Memorial Sloan-Kettering Cancer Center
University of Edinburgh
New York University
Netherlands Cancer Institute
University of Texas MD Anderson Cancer Center
Broad Institute of Harvard University and Massachusetts Institute of Technology
Massachusetts Institute of Technology
Harvard University
European Molecular Biology Laboratory
Utrecht University
Wellcome Sanger Institute
University of California at San Francisco

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Abstract

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Original language	English
Article number	e27041
Journal	eLife
Volume	6
Number of pages	30
ISSN	2050-084X
DOIs	https://doi.org/10.7554/eLife.27041
Publication status	Published - 2017

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., Clevers, H., Deplancke, B., Dunham, I., Eberwine, J., Eils, R., Enard, W., Farmer, A., Fugger, L., Göttgens, B., ... Human Cell Atlas Meeting Participants (2017). The human cell atlas. eLife, 6, Article e27041. https://doi.org/10.7554/eLife.27041

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title = "The human cell atlas",

abstract = "The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.",

author = "Aviv Regev and Teichmann, \{Sarah A.\} and Lander, \{Eric S.\} and Ido Amit and Christophe Benoist and Ewan Birney and Bernd Bodenmiller and Peter Campbell and Piero Carninci and Menna Clatworthy and Hans Clevers and Bart Deplancke and Ian Dunham and James Eberwine and Roland Eils and Wolfgang Enard and Andrew Farmer and Lars Fugger and Berthold G{\"o}ttgens and Nir Hacohen and Muzlifah Haniffa and Martin Hemberg and Seung Kim and Paul Klenerman and Arnold Kriegstein and Ed Lein and Sten Linnarsson and Emma Lundberg and Joakim Lundeberg and Partha Majumder and Marioni, \{John C.\} and Miriam Merad and Musa Mhlanga and Martijn Nawijn and Mihai Netea and Garry Nolan and Dana Pe{\textquoteright}er and Anthony Phillipakis and Ponting, \{Chris P.\} and Stephen Quake and Wolf Reik and Orit Rozenblatt-Rosen and Joshua Sanes and Rahul Satija and Schumacher, \{Ton N.\} and Alex Shalek and Ehud Shapiro and Padmanee Sharma and Shin, \{Jay W.\} and Mathias Uhl{\'e}n and \{Human Cell Atlas Meeting Participants\}",

note = "This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.",

year = "2017",

doi = "10.7554/eLife.27041",

language = "English",

volume = "6",

journal = "eLife",

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Regev, A, Teichmann, SA, Lander, ES, Amit, I, Benoist, C, Birney, E, Bodenmiller, B, Campbell, P, Carninci, P, Clatworthy, M, Clevers, H, Deplancke, B, Dunham, I, Eberwine, J, Eils, R, Enard, W, Farmer, A, Fugger, L, Göttgens, B, Hacohen, N, Haniffa, M, Hemberg, M, Kim, S, Klenerman, P, Kriegstein, A, Lein, E, Linnarsson, S, Lundberg, E, Lundeberg, J, Majumder, P, Marioni, JC, Merad, M, Mhlanga, M, Nawijn, M, Netea, M, Nolan, G, Pe’er, D, Phillipakis, A, Ponting, CP, Quake, S, Reik, W, Rozenblatt-Rosen, O, Sanes, J, Satija, R, Schumacher, TN, Shalek, A, Shapiro, E, Sharma, P, Shin, JW, Uhlén, M & Human Cell Atlas Meeting Participants 2017, 'The human cell atlas', eLife, vol. 6, e27041. https://doi.org/10.7554/eLife.27041

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AU - Regev, Aviv

AU - Teichmann, Sarah A.

AU - Lander, Eric S.

AU - Amit, Ido

AU - Benoist, Christophe

AU - Birney, Ewan

AU - Bodenmiller, Bernd

AU - Campbell, Peter

AU - Carninci, Piero

AU - Clatworthy, Menna

AU - Clevers, Hans

AU - Deplancke, Bart

AU - Dunham, Ian

AU - Eberwine, James

AU - Eils, Roland

AU - Enard, Wolfgang

AU - Farmer, Andrew

AU - Fugger, Lars

AU - Göttgens, Berthold

AU - Hacohen, Nir

AU - Haniffa, Muzlifah

AU - Hemberg, Martin

AU - Kim, Seung

AU - Klenerman, Paul

AU - Kriegstein, Arnold

AU - Lein, Ed

AU - Linnarsson, Sten

AU - Lundberg, Emma

AU - Lundeberg, Joakim

AU - Majumder, Partha

AU - Marioni, John C.

AU - Merad, Miriam

AU - Mhlanga, Musa

AU - Nawijn, Martijn

AU - Netea, Mihai

AU - Nolan, Garry

AU - Pe’er, Dana

AU - Phillipakis, Anthony

AU - Ponting, Chris P.

AU - Quake, Stephen

AU - Reik, Wolf

AU - Rozenblatt-Rosen, Orit

AU - Sanes, Joshua

AU - Satija, Rahul

AU - Schumacher, Ton N.

AU - Shalek, Alex

AU - Shapiro, Ehud

AU - Sharma, Padmanee

AU - Shin, Jay W.

AU - Uhlén, Mathias

AU - Human Cell Atlas Meeting Participants

N1 - This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PY - 2017

Y1 - 2017

N2 - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

AB - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

U2 - 10.7554/eLife.27041

DO - 10.7554/eLife.27041

M3 - Journal article

C2 - 29206104

AN - SCOPUS:85040459896

SN - 2050-084X

VL - 6

JO - eLife

JF - eLife

M1 - e27041

ER -

The human cell atlas

Abstract

Bibliographical note

UN SDGs

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