The human cell atlas

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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  • Author: Regev, Aviv

    Massachusetts Institute of Technology

  • Author: Teichmann, Sarah A.

    University of Cambridge

  • Author: Lander, Eric S.

    Massachusetts Institute of Technology

  • Author: Amit, Ido

    Weizmann Institute of Science

  • Author: Benoist, Christophe

    Harvard University

  • Author: Birney, Ewan

    European Molecular Biology Laboratory

  • Author: Bodenmiller, Bernd

    University of Zurich

  • Author: Campbell, Peter G. C.

    University of Cambridge

  • Author: Carninci, Piero

    RIKEN

  • Author: Clatworthy, Menna

    University of Cambridge

  • Author: Clevers, Hans

    Utrecht University

  • Author: Deplancke, Bart

    Swiss Federal Institute of Technology Lausanne

  • Author: Dunham, Ian

    European Molecular Biology Laboratory

  • Author: Eberwine, James

    University of Pennsylvania

  • Author: Eils, Roland

    Heidelberg University 

  • Author: Enard, Wolfgang

    Ludwig Maximilian University of Munich

  • Author: Farmer, Andrew

    Takara Bio USA, Inc.

  • Author: Fugger, Lars

    University of Oxford

  • Author: Göttgens, Berthold

    University of Cambridge

  • Author: Hacohen, Nir

    Harvard University

  • Author: Haniffa, Muzlifah

    Newcastle University

  • Author: Hemberg, Martin

    Wellcome Sanger Institute

  • Author: Kim, Seung Jin

    Stanford University

  • Author: Klenerman, Paul

    University of Oxford

  • Author: Kriegstein, Arnold

    University of California at San Francisco

  • Author: Lein, Ed

    Allen Institute for Brain Science

  • Author: Linnarsson, Sten

    Karolinska Institutet

  • Author: Lundberg, Emma

    Royal Institute of Technology

  • Author: Lundeberg, Joakim

    Royal Institute of Technology

  • Author: Majumder, Partha

    National Institute of Biomedical Genomics

  • Author: Marioni, John C.

    University of Cambridge

  • Author: Merad, Miriam

    Icahn School of Medicine at Mount Sinai

  • Author: Mhlanga, Musa

    University of Cape Town

  • Author: Nawijn, Martijn

    University of Groningen

  • Author: Netea, Mihai G.

    Radboud University Nijmegen

  • Author: Nolan, Garry P

    Stanford University

  • Author: Pe’er, Dana

    Memorial Sloan-Kettering Cancer Center

  • Author: Phillipakis, Anthony A.

    Broad Institute

  • Author: Ponting, Chris P.

    University of Edinburgh

  • Author: Quake, Stephen R.

    Stanford University

  • Author: Reik, Wolf

    University of Cambridge

  • Author: Rozenblatt-Rosen, Orit

    Broad Institute

  • Author: Sanes, Joshua

    Harvard University

  • Author: Satija, Rahul

    New York University

  • Author: Schumacher, Ton N.

    Netherlands Cancer Institute

  • Author: Shalek, Alex

    Massachusetts Institute of Technology

  • Author: Shapiro, Ehud

    Weizmann Institute of Science

  • Author: Sharma, Padmanee

    University of Texas MD Anderson Cancer Center

  • Author: Shin, Jay W.

    RIKEN

  • Author: Uhlén, Mathias

    High Throughput Molecular Bioscience, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark

  • Author: Human Cell Atlas Meeting Participants

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The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

Original languageEnglish
Article numbere27041
JournaleLife
Volume6
Number of pages30
ISSN2050-084X
DOIs
Publication statusPublished - 2017

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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