The gut microbiome in atherosclerotic cardiovascular disease

Zhuye Jie, Huihua Xia, Shi-Long Zhong, Qiang Feng, Shenghui Li, Suisha Liang, Huanzi Zhong, Zhipeng Liu, Yuan Gao, Hui Zhao, Dongya Zhang, Zheng Su, Zhiwei Fang, Zhou Lan, Junhua Li, Liang Xiao, Jun Li, Ruijun Li, Xiaoping Li, Fei LiHuahui Ren, Yan Huang, Yangqing Peng, Guanglei Li, Bo Wen, Bo Dong, Ji-Yan Chen, Qing-Shan Geng, Zhi-Wei Zhang, Huanming Yang, Jian Wang, Jun Wang, Xuan Zhang, Lise Madsen, Susanne Brix, Guang Ning, Xun Xu, Xin Liu, Yong Hou, Huijue Jia, Kunlun He, Karsten Kristiansen

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Abstract

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform a metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls, identifying microbial strains and functions associated with the disease.
Original languageEnglish
Article number845
JournalNature Communications
Volume8
Issue number1
Number of pages12
ISSN2041-1723
DOIs
Publication statusPublished - 2017

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Cite this

Jie, Z., Xia, H., Zhong, S-L., Feng, Q., Li, S., Liang, S., Zhong, H., Liu, Z., Gao, Y., Zhao, H., Zhang, D., Su, Z., Fang, Z., Lan, Z., Li, J., Xiao, L., Li, J., Li, R., Li, X., ... Kristiansen, K. (2017). The gut microbiome in atherosclerotic cardiovascular disease. Nature Communications, 8(1), [845]. https://doi.org/10.1038/s41467-017-00900-1