The global antigenic diversity of swine influenza A viruses

Nicola S Lewis; Colin A Russell; Pinky Langat; Tavis K Anderson; Kathryn Berger; Filip Bielejec; David F Burke; Gytis Dudas; Judith M Fonville; Ron Am Fouchier; Paul Kellam; Bjorn F Koel; Philippe Lemey; Tung Nguyen; Bundit Nuansrichy; Js Malik Peiris; Takehiko Saito; Gaelle Simon; Eugene Skepner; Nobuhiro Takemae; ESNIP3 consortium; Richard J Webby; Kristien Van Reeth; Sharon M Brookes; Lars Erik Larsen; Simon J Watson; Ian H Brown; Amy L Vincent

doi:10.7554/eLife.12217

The global antigenic diversity of swine influenza A viruses

Nicola S Lewis, Colin A Russell, Pinky Langat, Tavis K Anderson, Kathryn Berger, Filip Bielejec, David F Burke, Gytis Dudas, Judith M Fonville, Ron Am Fouchier, Paul Kellam, Bjorn F Koel, Philippe Lemey, Tung Nguyen, Bundit Nuansrichy, Js Malik Peiris, Takehiko Saito, Gaelle Simon, Eugene Skepner, Nobuhiro TakemaeESNIP3 consortium, Richard J Webby, Kristien Van Reeth, Sharon M Brookes, Lars Erik Larsen, Simon J Watson, Ian H Brown, Amy L Vincent

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Abstract

Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

Original language	English
Article number	e12217
Journal	eLife
Volume	5
Number of pages	17
ISSN	2050-084X
DOIs	https://doi.org/10.7554/eLife.12217
Publication status	Published - 2016

Keywords

epidemiology
global health
human
infectious disease
influenza
microbiology
pandemic
swine
virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Lewis, N. S., Russell, C. A., Langat, P., Anderson, T. K., Berger, K., Bielejec, F., Burke, D. F., Dudas, G., Fonville, J. M., Fouchier, R. A., Kellam, P., Koel, B. F., Lemey, P., Nguyen, T., Nuansrichy, B., Peiris, J. M., Saito, T., Simon, G., Skepner, E., ... Vincent, A. L. (2016). The global antigenic diversity of swine influenza A viruses. eLife, 5, Article e12217. https://doi.org/10.7554/eLife.12217

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title = "The global antigenic diversity of swine influenza A viruses",

abstract = "Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans. ",

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Lewis, NS, Russell, CA, Langat, P, Anderson, TK, Berger, K, Bielejec, F, Burke, DF, Dudas, G, Fonville, JM, Fouchier, RA, Kellam, P, Koel, BF, Lemey, P, Nguyen, T, Nuansrichy, B, Peiris, JM, Saito, T, Simon, G, Skepner, E, Takemae, N, consortium, ESNIP, Webby, RJ, Van Reeth, K, Brookes, SM, Larsen, LE, Watson, SJ, Brown, IH & Vincent, AL 2016, 'The global antigenic diversity of swine influenza A viruses', eLife, vol. 5, e12217. https://doi.org/10.7554/eLife.12217

TY - JOUR

T1 - The global antigenic diversity of swine influenza A viruses

AU - Lewis, Nicola S

AU - Russell, Colin A

AU - Langat, Pinky

AU - Anderson, Tavis K

AU - Berger, Kathryn

AU - Bielejec, Filip

AU - Burke, David F

AU - Dudas, Gytis

AU - Fonville, Judith M

AU - Fouchier, Ron Am

AU - Kellam, Paul

AU - Koel, Bjorn F

AU - Lemey, Philippe

AU - Nguyen, Tung

AU - Nuansrichy, Bundit

AU - Peiris, Js Malik

AU - Saito, Takehiko

AU - Simon, Gaelle

AU - Skepner, Eugene

AU - Takemae, Nobuhiro

AU - consortium, ESNIP3

AU - Webby, Richard J

AU - Van Reeth, Kristien

AU - Brookes, Sharon M

AU - Larsen, Lars Erik

AU - Watson, Simon J

AU - Brown, Ian H

AU - Vincent, Amy L

PY - 2016

Y1 - 2016

N2 - Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

AB - Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

KW - epidemiology

KW - global health

KW - human

KW - infectious disease

KW - influenza

KW - microbiology

KW - pandemic

KW - swine

KW - virus

U2 - 10.7554/eLife.12217

DO - 10.7554/eLife.12217

M3 - Journal article

C2 - 27113719

SN - 2050-084X

VL - 5

JO - eLife

JF - eLife

M1 - e12217

ER -

The global antigenic diversity of swine influenza A viruses

Abstract

Keywords

UN SDGs

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