The foot-and-mouth disease virus cis-acting replication element (cre) can be complemented in trans within infected cells

L. Tiley, A. M. Q. King, Graham Belsham

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A temperature-sensitive (ts) mutation was identified within the 5'-untranslated region of foot-and-mouth disease virus (FMDV) RNA. The mutation destabilizes a stem-loop structure recently identified as a cis-acting replication element (cre). Genetic analyses indicated that the ts defect in virus replication could be complemented. Thus, the FMDV cre can function in trans. It is suggested that the cre be renamed a 3B-uridylylation site (bus).
Original languageEnglish
JournalJournal of Virology
Volume77
Issue number3
Pages (from-to)2243-2246
ISSN0022-538X
DOIs
Publication statusPublished - 2003
Externally publishedYes

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