The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome

Kang Kang, Yueqiong Ni, Jun Li, Lejla Imamovic, Chinmoy Sarkar, Marie Danielle Kobler, Yoshitaro Heshiki, Tingting Zheng, Sarika Kumari, Jane Ching Yan Wong, Anand Archna, Cheong Wai Martin Wong, Caroline Dingle, Seth Denizen, David Michael Baker, Morten Otto Alexander Sommer, Christopher John Webster, Gianni Panagiotou*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact with handrails within the Hong Kong Mass Transit Railway (MTR) system. Intraday sampling time was identified as the primary determinant of the variation and recurrence of the community composition, whereas human-associated species and clinically important antibiotic resistance genes (ARGs) were captured as p.m. signatures. Line-specific signatures were notably correlated with line-specific environmental exposures and city characteristics. The sole cross-border line appeared as an outlier in most analyses and showed high relative abundance and a significant intraday increment of clinically important ARGs (24.1%), suggesting potential cross-border ARG transmission, especially for tetracycline and vancomycin resistance. Our study provides an important reference for future public health strategies to mitigate intracity and cross-border pathogen and ARG transmission. 

Original languageEnglish
JournalCell Reports
Volume24
Issue number5
Pages (from-to)1190-1202
ISSN2211-1247
DOIs
Publication statusPublished - 2018

Bibliographical note

open access under a Creative Commons license: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Keywords

  • Antibiotic resistance gene
  • ARG
  • ARG transmission
  • Metagenomics
  • Metro system
  • Microbial signature
  • Microbiome
  • Recurrence
  • Skin

Cite this

Kang, Kang ; Ni, Yueqiong ; Li, Jun ; Imamovic, Lejla ; Sarkar, Chinmoy ; Kobler, Marie Danielle ; Heshiki, Yoshitaro ; Zheng, Tingting ; Kumari, Sarika ; Wong, Jane Ching Yan ; Archna, Anand ; Wong, Cheong Wai Martin ; Dingle, Caroline ; Denizen, Seth ; Baker, David Michael ; Sommer, Morten Otto Alexander ; Webster, Christopher John ; Panagiotou, Gianni. / The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome. In: Cell Reports. 2018 ; Vol. 24, No. 5. pp. 1190-1202.
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title = "The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome",
abstract = "The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact with handrails within the Hong Kong Mass Transit Railway (MTR) system. Intraday sampling time was identified as the primary determinant of the variation and recurrence of the community composition, whereas human-associated species and clinically important antibiotic resistance genes (ARGs) were captured as p.m. signatures. Line-specific signatures were notably correlated with line-specific environmental exposures and city characteristics. The sole cross-border line appeared as an outlier in most analyses and showed high relative abundance and a significant intraday increment of clinically important ARGs (24.1{\%}), suggesting potential cross-border ARG transmission, especially for tetracycline and vancomycin resistance. Our study provides an important reference for future public health strategies to mitigate intracity and cross-border pathogen and ARG transmission. ",
keywords = "Antibiotic resistance gene, ARG, ARG transmission, Metagenomics, Metro system, Microbial signature, Microbiome, Recurrence, Skin",
author = "Kang Kang and Yueqiong Ni and Jun Li and Lejla Imamovic and Chinmoy Sarkar and Kobler, {Marie Danielle} and Yoshitaro Heshiki and Tingting Zheng and Sarika Kumari and Wong, {Jane Ching Yan} and Anand Archna and Wong, {Cheong Wai Martin} and Caroline Dingle and Seth Denizen and Baker, {David Michael} and Sommer, {Morten Otto Alexander} and Webster, {Christopher John} and Gianni Panagiotou",
note = "open access under a Creative Commons license: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)",
year = "2018",
doi = "10.1016/j.celrep.2018.06.109",
language = "English",
volume = "24",
pages = "1190--1202",
journal = "Cell Reports",
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Kang, K, Ni, Y, Li, J, Imamovic, L, Sarkar, C, Kobler, MD, Heshiki, Y, Zheng, T, Kumari, S, Wong, JCY, Archna, A, Wong, CWM, Dingle, C, Denizen, S, Baker, DM, Sommer, MOA, Webster, CJ & Panagiotou, G 2018, 'The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome', Cell Reports, vol. 24, no. 5, pp. 1190-1202. https://doi.org/10.1016/j.celrep.2018.06.109

The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome. / Kang, Kang; Ni, Yueqiong; Li, Jun; Imamovic, Lejla; Sarkar, Chinmoy; Kobler, Marie Danielle; Heshiki, Yoshitaro; Zheng, Tingting; Kumari, Sarika; Wong, Jane Ching Yan; Archna, Anand; Wong, Cheong Wai Martin; Dingle, Caroline; Denizen, Seth; Baker, David Michael; Sommer, Morten Otto Alexander; Webster, Christopher John; Panagiotou, Gianni.

In: Cell Reports, Vol. 24, No. 5, 2018, p. 1190-1202.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Skin Microbiome and Resistome

AU - Kang, Kang

AU - Ni, Yueqiong

AU - Li, Jun

AU - Imamovic, Lejla

AU - Sarkar, Chinmoy

AU - Kobler, Marie Danielle

AU - Heshiki, Yoshitaro

AU - Zheng, Tingting

AU - Kumari, Sarika

AU - Wong, Jane Ching Yan

AU - Archna, Anand

AU - Wong, Cheong Wai Martin

AU - Dingle, Caroline

AU - Denizen, Seth

AU - Baker, David Michael

AU - Sommer, Morten Otto Alexander

AU - Webster, Christopher John

AU - Panagiotou, Gianni

N1 - open access under a Creative Commons license: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

PY - 2018

Y1 - 2018

N2 - The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact with handrails within the Hong Kong Mass Transit Railway (MTR) system. Intraday sampling time was identified as the primary determinant of the variation and recurrence of the community composition, whereas human-associated species and clinically important antibiotic resistance genes (ARGs) were captured as p.m. signatures. Line-specific signatures were notably correlated with line-specific environmental exposures and city characteristics. The sole cross-border line appeared as an outlier in most analyses and showed high relative abundance and a significant intraday increment of clinically important ARGs (24.1%), suggesting potential cross-border ARG transmission, especially for tetracycline and vancomycin resistance. Our study provides an important reference for future public health strategies to mitigate intracity and cross-border pathogen and ARG transmission. 

AB - The skin functions as the primary interface between the human body and the external environment. To understand how the microbiome varies within urban mass transit and influences the skin microbiota, we profiled the human palm microbiome after contact with handrails within the Hong Kong Mass Transit Railway (MTR) system. Intraday sampling time was identified as the primary determinant of the variation and recurrence of the community composition, whereas human-associated species and clinically important antibiotic resistance genes (ARGs) were captured as p.m. signatures. Line-specific signatures were notably correlated with line-specific environmental exposures and city characteristics. The sole cross-border line appeared as an outlier in most analyses and showed high relative abundance and a significant intraday increment of clinically important ARGs (24.1%), suggesting potential cross-border ARG transmission, especially for tetracycline and vancomycin resistance. Our study provides an important reference for future public health strategies to mitigate intracity and cross-border pathogen and ARG transmission. 

KW - Antibiotic resistance gene

KW - ARG

KW - ARG transmission

KW - Metagenomics

KW - Metro system

KW - Microbial signature

KW - Microbiome

KW - Recurrence

KW - Skin

U2 - 10.1016/j.celrep.2018.06.109

DO - 10.1016/j.celrep.2018.06.109

M3 - Journal article

VL - 24

SP - 1190

EP - 1202

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 5

ER -