The efficacy of CP7_E2alf: an animal study involving piglets from C–strain vaccinated sows

Desislava Yordanova Rangelova, Jens Nielsen, Bertel Strandbygaard, Sandra Blome, Åse Uttenthal

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    Abstract

    Outbreaks of Classical Swine Fever (CSF) in the European Union have caused enormous economical losses. To facilitate the possibility of free trade with pigs and their products, a chimeric live DIVA vaccine CP7_E2alf was developed. Most likely, passive immunity against CSF virus in populations previously vaccinated with C-strain interferes with the efficacy of CP7_E2alf vaccination. To study the interaction with maternal antibodies, the efficacy of CP7_E2alf in piglets from C-strain vaccinated sows was examined. At 5 or at 8 weeks of age, piglets were vaccinated with CP7_E2alf. The vaccinated piglets together with mock-vaccinated littermate controls were challenged 2 weeks post vaccination with highly virulent CSFV Kozlov. The results showed that CP7_E2alf is effective in preventing mortality, severe clinical signs and pathological lesions in piglets vaccinated at 5 or at 8 weeks of age. Interestingly, the antibodies in the mock-vaccinated control piglets partly neutralized the challenge virus. In earlier studies CSFV Koslov has resulted in 100% mortality in naïve piglets, in this study mortality was reduced to 30% in the piglets infected at 7 weeks of age and to 50% in the piglets infected at 10 weeks of age. In the present study optimal time point for vaccination of piglets with passive immunity was found to be 5 weeks of age.
    Original languageEnglish
    Publication date2012
    Number of pages41
    Publication statusPublished - 2012
    EventAnnual Meeting of the National Reference Laboratories of CSF - Hannover, Germany
    Duration: 1 Jul 20121 Jul 2012

    Conference

    ConferenceAnnual Meeting of the National Reference Laboratories of CSF
    CountryGermany
    CityHannover
    Period01/07/201201/07/2012

    Bibliographical note

    Oral presentation at the 2012 Annual Meeting of the National Reference Laboratories of CSF

    Activities

    • 1 Talks and presentations in private or public companies and organisations

    National reference laboratories swine fevers

    Åse Uttenthal (Speaker)

    6 Jun 2012

    Activity: Talks and presentationsTalks and presentations in private or public companies and organisations

    Cite this

    Rangelova, D. Y., Nielsen, J., Strandbygaard, B., Blome, S., & Uttenthal, Å. (2012). The efficacy of CP7_E2alf: an animal study involving piglets from C–strain vaccinated sows. Abstract from Annual Meeting of the National Reference Laboratories of CSF, Hannover, Germany.