The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells

C.T. Damsgaard, Hanne Frøkiær, L. Lauritzen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Dietary intake of 18: 2n-6 and 18: 3n-3 may affect endogenous production and incorporation of n-3 long-chain PUFA (LCPUFA) from fish oils (170). This double-blinded controlled 2 x 2-factorial 8-week intervention investigates the effects of high and low 18: 2n-6 intake in combination with FO-supplementation on tissue fatty acid composition. Healthy young men (it 64) were randomized to capsules with FO or olive oil (control) (4-4 (2-0-5-6) ml/d) and to either sunflower oil and margarine (S/B) or rapeseed oil and a butter spread (R/K) to provide a high or a low 18: 2n-6 intake. Diet was measured by 4-d weighed dietary records at baseline, during and 8 weeks after the intervention and tissue incorporation as fatty acid composition of peripheral blood mononuclear cells (PBMC). The fat intervention gave a mean difference in the 18: 2n-6 intake of 7.3 g/d (95 % CI 4-6, 10-0) and a similar 18: 3n-3 intake in the groups. The R/K groups had a 0.2 % fatty acid (FA%) (95 % CI 0.0, 0.4, P=0.02) higher content of 22: 5n-3 in the PBMC, a tendency of slightly higher 20: 5n-3 (P=0.06), but no more 22: 6n-3 (P=0.83) than the SIB groups. FO effectively raised the PBMC content of all n-3 LCPUFA (P
    Original languageEnglish
    JournalBritish Journal of Nutrition
    Volume99
    Issue number1
    Pages (from-to)147-154
    ISSN0007-1145
    Publication statusPublished - 2008

    Keywords

    • fish oil
    • linoleic acid
    • PUFA
    • incorporation
    • mononuclear cell

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