The effect of discontinued use of antimicrobial growth promoters on the risk of therapeutic antibiotic treatment in Danish farrow-to-finish pig farms

Håkan Vigre, P.B. Larsen, Morten Andreasen, Julia Christensen, Sven Erik Lind Jorsal

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    This study estimated the effect of discontinued use of antimicrobial growth promoters (duAGPs) oil the risk of antibiotic treatment for diarrhoea, arthritis. pneumonia, unthriving and miscellaneous disorders in Danish pig farms. The estimation was done in a case-crossover study comparing: (1) the proportion of days per farm where treatment was performed (PDT) and (2) the proportion of pigs treated per day per farm at days where treatment was performed (PPT) before and after duAGPs at 68 farrow-to-finish farms. The farms were selected using, a two-stage (veterinarian/farm) convenience sampling. On average, during the first year after duAGPs there was a significant increase in the risk of antibiotic treatment for diarrhoea (PDT: OR 2.5. 95% CI 1.7-3.8; PPT: OR 1.6, 95% CI 1.1-2.2). However, the effect varied among farms - some farms experienced substantial problems, while others experienced few problems after duAGPs. No effect was identified for the risk of treatment for other diseases.
    Original languageEnglish
    JournalEpidemiology and Infection
    Volume136
    Issue number1
    Pages (from-to)92-107
    ISSN0950-2688
    DOIs
    Publication statusPublished - 2008

    Cite this

    Vigre, Håkan ; Larsen, P.B. ; Andreasen, Morten ; Christensen, Julia ; Jorsal, Sven Erik Lind. / The effect of discontinued use of antimicrobial growth promoters on the risk of therapeutic antibiotic treatment in Danish farrow-to-finish pig farms. In: Epidemiology and Infection. 2008 ; Vol. 136, No. 1. pp. 92-107.
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    abstract = "This study estimated the effect of discontinued use of antimicrobial growth promoters (duAGPs) oil the risk of antibiotic treatment for diarrhoea, arthritis. pneumonia, unthriving and miscellaneous disorders in Danish pig farms. The estimation was done in a case-crossover study comparing: (1) the proportion of days per farm where treatment was performed (PDT) and (2) the proportion of pigs treated per day per farm at days where treatment was performed (PPT) before and after duAGPs at 68 farrow-to-finish farms. The farms were selected using, a two-stage (veterinarian/farm) convenience sampling. On average, during the first year after duAGPs there was a significant increase in the risk of antibiotic treatment for diarrhoea (PDT: OR 2.5. 95{\%} CI 1.7-3.8; PPT: OR 1.6, 95{\%} CI 1.1-2.2). However, the effect varied among farms - some farms experienced substantial problems, while others experienced few problems after duAGPs. No effect was identified for the risk of treatment for other diseases.",
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    The effect of discontinued use of antimicrobial growth promoters on the risk of therapeutic antibiotic treatment in Danish farrow-to-finish pig farms. / Vigre, Håkan; Larsen, P.B.; Andreasen, Morten; Christensen, Julia; Jorsal, Sven Erik Lind.

    In: Epidemiology and Infection, Vol. 136, No. 1, 2008, p. 92-107.

    Research output: Contribution to journalJournal articleResearchpeer-review

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    T1 - The effect of discontinued use of antimicrobial growth promoters on the risk of therapeutic antibiotic treatment in Danish farrow-to-finish pig farms

    AU - Vigre, Håkan

    AU - Larsen, P.B.

    AU - Andreasen, Morten

    AU - Christensen, Julia

    AU - Jorsal, Sven Erik Lind

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    N2 - This study estimated the effect of discontinued use of antimicrobial growth promoters (duAGPs) oil the risk of antibiotic treatment for diarrhoea, arthritis. pneumonia, unthriving and miscellaneous disorders in Danish pig farms. The estimation was done in a case-crossover study comparing: (1) the proportion of days per farm where treatment was performed (PDT) and (2) the proportion of pigs treated per day per farm at days where treatment was performed (PPT) before and after duAGPs at 68 farrow-to-finish farms. The farms were selected using, a two-stage (veterinarian/farm) convenience sampling. On average, during the first year after duAGPs there was a significant increase in the risk of antibiotic treatment for diarrhoea (PDT: OR 2.5. 95% CI 1.7-3.8; PPT: OR 1.6, 95% CI 1.1-2.2). However, the effect varied among farms - some farms experienced substantial problems, while others experienced few problems after duAGPs. No effect was identified for the risk of treatment for other diseases.

    AB - This study estimated the effect of discontinued use of antimicrobial growth promoters (duAGPs) oil the risk of antibiotic treatment for diarrhoea, arthritis. pneumonia, unthriving and miscellaneous disorders in Danish pig farms. The estimation was done in a case-crossover study comparing: (1) the proportion of days per farm where treatment was performed (PDT) and (2) the proportion of pigs treated per day per farm at days where treatment was performed (PPT) before and after duAGPs at 68 farrow-to-finish farms. The farms were selected using, a two-stage (veterinarian/farm) convenience sampling. On average, during the first year after duAGPs there was a significant increase in the risk of antibiotic treatment for diarrhoea (PDT: OR 2.5. 95% CI 1.7-3.8; PPT: OR 1.6, 95% CI 1.1-2.2). However, the effect varied among farms - some farms experienced substantial problems, while others experienced few problems after duAGPs. No effect was identified for the risk of treatment for other diseases.

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