The Effect in Vitro of Ionizing Irradiation and Small Rises in Temperature on the Uptake and Release of Labelled Lipids by the Human Erythrocyte Membrane

Heinz Johs. Max Hansen, H. Karle, S. Stender

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    1. The effect of X-irradiation (50 000 rad) and an increase in temperature from 37 to 42° C on the synthesis, uptake and release of labelled lipids by erythrocytes was studied in plasma incubations in vitro. 2. Both irradiation and a rise in temperature resulted in an enhanced synthesis of [32P]phosphatidic acid in the erythrocytes. 3. The uptake by the erythrocytes of 14C- and 3H-labelled cholesterol, [14C, 32P]phosphatidylethanolamine and [14C, 32P]phosphatidylcholine from plasma lipoproteins was increased by a rise in temperature but not by irradiation. These labelled lipids were apparently taken up in the ratio in which they were found in plasma. They were not released from the erythrocytes in the same manner.
    Original languageEnglish
    JournalBBA General Subjects
    Volume528
    Issue number2
    Pages (from-to)230-238
    ISSN0304-4165
    DOIs
    Publication statusPublished - 1978

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