The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated

M. J. Denwood, M. J. Stear, L. Matthews, S. W. J. Reid, Nils Toft, G. T. Innocent

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Understanding the frequency distribution of parasites and parasite stages among hosts is essential for efficient experimental design and statistical analysis, and is also required for the development of sustainable methods of controlling infection. Nematodirus battus is one of the most important organisms that infect sheep but the distribution of parasites among hosts is unknown. An initial analysis indicated a high frequency of animals without N. battus and with zero egg counts, suggesting the possibility of a zero-inflated distribution. We developed a Bayesian analysis using Markov chain Monte Carlo methods to estimate the parameters of the zero-inflated negative binomial distribution. The analysis of 3000 simulated data sets indicated that this method out-performed the maximum likelihood procedure. Application of this technique to faecal egg counts from lambs in a commercial upland flock indicated that N. battus counts were indeed zero-inflated. Estimating the extent of zero-inflation is important for effective statistical analysis and for the accurate identification of genetically resistant animals. Copyright © 2008 Cambridge University Press.
Original languageEnglish
JournalParasitology
Volume135
Issue number10
Pages (from-to)1225-1235
Number of pages11
ISSN0031-1820
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Nematodirus battus
  • Ovis aries
  • distribution
  • Bayesian MCMC
  • faecal egg count
  • Zero-inflated negative binomial

Cite this

Denwood, M. J., Stear, M. J., Matthews, L., Reid, S. W. J., Toft, N., & Innocent, G. T. (2008). The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated. Parasitology, 135(10), 1225-1235. https://doi.org/10.1017/S0031182008004708
Denwood, M. J. ; Stear, M. J. ; Matthews, L. ; Reid, S. W. J. ; Toft, Nils ; Innocent, G. T. / The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated. In: Parasitology. 2008 ; Vol. 135, No. 10. pp. 1225-1235.
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abstract = "Understanding the frequency distribution of parasites and parasite stages among hosts is essential for efficient experimental design and statistical analysis, and is also required for the development of sustainable methods of controlling infection. Nematodirus battus is one of the most important organisms that infect sheep but the distribution of parasites among hosts is unknown. An initial analysis indicated a high frequency of animals without N. battus and with zero egg counts, suggesting the possibility of a zero-inflated distribution. We developed a Bayesian analysis using Markov chain Monte Carlo methods to estimate the parameters of the zero-inflated negative binomial distribution. The analysis of 3000 simulated data sets indicated that this method out-performed the maximum likelihood procedure. Application of this technique to faecal egg counts from lambs in a commercial upland flock indicated that N. battus counts were indeed zero-inflated. Estimating the extent of zero-inflation is important for effective statistical analysis and for the accurate identification of genetically resistant animals. Copyright {\circledC} 2008 Cambridge University Press.",
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Denwood, MJ, Stear, MJ, Matthews, L, Reid, SWJ, Toft, N & Innocent, GT 2008, 'The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated', Parasitology, vol. 135, no. 10, pp. 1225-1235. https://doi.org/10.1017/S0031182008004708

The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated. / Denwood, M. J.; Stear, M. J.; Matthews, L.; Reid, S. W. J.; Toft, Nils; Innocent, G. T.

In: Parasitology, Vol. 135, No. 10, 2008, p. 1225-1235.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - The distribution of the pathogenic nematode Nematodirus battus in lambs is zero-inflated

AU - Denwood, M. J.

AU - Stear, M. J.

AU - Matthews, L.

AU - Reid, S. W. J.

AU - Toft, Nils

AU - Innocent, G. T.

PY - 2008

Y1 - 2008

N2 - Understanding the frequency distribution of parasites and parasite stages among hosts is essential for efficient experimental design and statistical analysis, and is also required for the development of sustainable methods of controlling infection. Nematodirus battus is one of the most important organisms that infect sheep but the distribution of parasites among hosts is unknown. An initial analysis indicated a high frequency of animals without N. battus and with zero egg counts, suggesting the possibility of a zero-inflated distribution. We developed a Bayesian analysis using Markov chain Monte Carlo methods to estimate the parameters of the zero-inflated negative binomial distribution. The analysis of 3000 simulated data sets indicated that this method out-performed the maximum likelihood procedure. Application of this technique to faecal egg counts from lambs in a commercial upland flock indicated that N. battus counts were indeed zero-inflated. Estimating the extent of zero-inflation is important for effective statistical analysis and for the accurate identification of genetically resistant animals. Copyright © 2008 Cambridge University Press.

AB - Understanding the frequency distribution of parasites and parasite stages among hosts is essential for efficient experimental design and statistical analysis, and is also required for the development of sustainable methods of controlling infection. Nematodirus battus is one of the most important organisms that infect sheep but the distribution of parasites among hosts is unknown. An initial analysis indicated a high frequency of animals without N. battus and with zero egg counts, suggesting the possibility of a zero-inflated distribution. We developed a Bayesian analysis using Markov chain Monte Carlo methods to estimate the parameters of the zero-inflated negative binomial distribution. The analysis of 3000 simulated data sets indicated that this method out-performed the maximum likelihood procedure. Application of this technique to faecal egg counts from lambs in a commercial upland flock indicated that N. battus counts were indeed zero-inflated. Estimating the extent of zero-inflation is important for effective statistical analysis and for the accurate identification of genetically resistant animals. Copyright © 2008 Cambridge University Press.

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