The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Xueling Quan; Rokon Uddin; Arto Heiskanen; Mattias Parmvi; Katharina Nilson; Marco Donolato; Mikkel Fougt Hansen; Graham Rena; Anja Boisen

doi:10.1039/c5cc04321b

The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Xueling Quan
, Rokon Uddin
, Arto Heiskanen
, Mattias Parmvi
, Katharina Nilson
, Marco Donolato
, Mikkel Fougt Hansen
, Graham Rena
, Anja Boisen

University of Dundee

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

Original language	English
Journal	Chemical Communications
Volume	51
Issue number	97
Pages (from-to)	17313-17316
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c5cc04321b
Publication status	Published - 2015

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SDG 3 Good Health and Well-being

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10.1039/c5cc04321b

C5cc04321b 1Accepted author manuscript, 1.3 MB

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title = "The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration",

abstract = "Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function. ",

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AU - Uddin, Rokon

AU - Heiskanen, Arto

AU - Parmvi, Mattias

AU - Nilson, Katharina

AU - Donolato, Marco

AU - Hansen, Mikkel Fougt

AU - Rena, Graham

AU - Boisen, Anja

PY - 2015

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AB - Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

U2 - 10.1039/c5cc04321b

DO - 10.1039/c5cc04321b

M3 - Journal article

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SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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ER -

The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Abstract

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