The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration

Xueling Quan, Rokon Uddin, Arto Heiskanen, Mattias Parmvi, Katharina Nilson, Marco Donolato, Mikkel Fougt Hansen, Graham Rena, Anja Boisen

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Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and l-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.
Original languageEnglish
JournalChemical Communications
Volume51
Issue number97
Pages (from-to)17313-17316
ISSN1359-7345
DOIs
Publication statusPublished - 2015

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