The CONNECT project: Combining macro- and micro-structure

Yaniv  Assaf; Daniel C. Alexander; Derek K. Jones; Albero  Bizzi; Tim E.J.  Behrens; Chris A.  Clark; Yoram  Cohen; Tim B. Dyrby; Petra S.  Huppi; Thomas R.  Knösche; Denis  LeBihan; Geoff J.M.  Parker; Cyril  Poupon; Matthew George Liptrot

doi:10.1016/j.neuroimage.2013.05.055

The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf, Daniel C. Alexander, Derek K. Jones, Albero Bizzi, Tim E.J. Behrens, Chris A. Clark, Yoram Cohen, Tim B. Dyrby, Petra S. Huppi, Thomas R. Knösche, Denis LeBihan, Geoff J.M. Parker, Cyril Poupon, Matthew George Liptrot

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.

The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

Original language	English
Journal	NeuroImage
Volume	80
Issue number	October
Pages (from-to)	273-282
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2013.05.055
Publication status	Published - 2013
Externally published	Yes

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title = "The CONNECT project: Combining macro- and micro-structure",

abstract = "In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.",

author = "Yaniv Assaf and Alexander, {Daniel C.} and Jones, {Derek K.} and Albero Bizzi and Behrens, {Tim E.J.} and Clark, {Chris A.} and Yoram Cohen and Dyrby, {Tim B.} and Huppi, {Petra S.} and Kn{\"o}sche, {Thomas R.} and Denis LeBihan and Parker, {Geoff J.M.} and Cyril Poupon and Liptrot, {Matthew George}",

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doi = "10.1016/j.neuroimage.2013.05.055",

language = "English",

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AU - Assaf, Yaniv

AU - Alexander, Daniel C.

AU - Jones, Derek K.

AU - Bizzi, Albero

AU - Behrens, Tim E.J.

AU - Clark, Chris A.

AU - Cohen, Yoram

AU - Dyrby, Tim B.

AU - Huppi, Petra S.

AU - Knösche, Thomas R.

AU - LeBihan, Denis

AU - Parker, Geoff J.M.

AU - Poupon, Cyril

AU - Liptrot, Matthew George

PY - 2013

Y1 - 2013

N2 - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

AB - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

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SN - 1053-8119

VL - 80

SP - 273

EP - 282

JO - NeuroImage

JF - NeuroImage

IS - October

ER -

The CONNECT project: Combining macro- and micro-structure

Abstract

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