The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf, Daniel C. Alexander, Derek K. Jones, Albero Bizzi, Tim E.J. Behrens, Chris A. Clark, Yoram Cohen, Tim B. Dyrby, Petra S. Huppi, Thomas R. Knösche, Denis LeBihan, Geoff J.M. Parker, Cyril Poupon, Matthew George Liptrot

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.

The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.
Original languageEnglish
JournalNeuroImage
Volume80
Issue numberOctober
Pages (from-to)273-282
ISSN1053-8119
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this

Assaf, Y., Alexander, D. C., Jones, D. K., Bizzi, A., Behrens, T. E. J., Clark, C. A., ... Liptrot, M. G. (2013). The CONNECT project: Combining macro- and micro-structure. NeuroImage, 80(October), 273-282. https://doi.org/10.1016/j.neuroimage.2013.05.055
Assaf, Yaniv ; Alexander, Daniel C. ; Jones, Derek K. ; Bizzi, Albero ; Behrens, Tim E.J. ; Clark, Chris A. ; Cohen, Yoram ; Dyrby, Tim B. ; Huppi, Petra S. ; Knösche, Thomas R. ; LeBihan, Denis ; Parker, Geoff J.M. ; Poupon, Cyril ; Liptrot, Matthew George. / The CONNECT project: Combining macro- and micro-structure. In: NeuroImage. 2013 ; Vol. 80, No. October. pp. 273-282.
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author = "Yaniv Assaf and Alexander, {Daniel C.} and Jones, {Derek K.} and Albero Bizzi and Behrens, {Tim E.J.} and Clark, {Chris A.} and Yoram Cohen and Dyrby, {Tim B.} and Huppi, {Petra S.} and Kn{\"o}sche, {Thomas R.} and Denis LeBihan and Parker, {Geoff J.M.} and Cyril Poupon and Liptrot, {Matthew George}",
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Assaf, Y, Alexander, DC, Jones, DK, Bizzi, A, Behrens, TEJ, Clark, CA, Cohen, Y, Dyrby, TB, Huppi, PS, Knösche, TR, LeBihan, D, Parker, GJM, Poupon, C & Liptrot, MG 2013, 'The CONNECT project: Combining macro- and micro-structure', NeuroImage, vol. 80, no. October, pp. 273-282. https://doi.org/10.1016/j.neuroimage.2013.05.055

The CONNECT project: Combining macro- and micro-structure. / Assaf, Yaniv ; Alexander, Daniel C.; Jones, Derek K.; Bizzi, Albero ; Behrens, Tim E.J. ; Clark, Chris A. ; Cohen, Yoram ; Dyrby, Tim B.; Huppi, Petra S. ; Knösche, Thomas R. ; LeBihan, Denis ; Parker, Geoff J.M. ; Poupon, Cyril ; Liptrot, Matthew George.

In: NeuroImage, Vol. 80, No. October, 2013, p. 273-282.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The CONNECT project: Combining macro- and micro-structure

AU - Assaf, Yaniv

AU - Alexander, Daniel C.

AU - Jones, Derek K.

AU - Bizzi, Albero

AU - Behrens, Tim E.J.

AU - Clark, Chris A.

AU - Cohen, Yoram

AU - Dyrby, Tim B.

AU - Huppi, Petra S.

AU - Knösche, Thomas R.

AU - LeBihan, Denis

AU - Parker, Geoff J.M.

AU - Poupon, Cyril

AU - Liptrot, Matthew George

PY - 2013

Y1 - 2013

N2 - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

AB - In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

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DO - 10.1016/j.neuroimage.2013.05.055

M3 - Journal article

C2 - 23727318

VL - 80

SP - 273

EP - 282

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - October

ER -

Assaf Y, Alexander DC, Jones DK, Bizzi A, Behrens TEJ, Clark CA et al. The CONNECT project: Combining macro- and micro-structure. NeuroImage. 2013;80(October):273-282. https://doi.org/10.1016/j.neuroimage.2013.05.055