The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer

Zsolt Baranyai, Marcin Krzystanek, Valeria Josa, Kristof Dede, E. Ágoston, A. Marcell Szasz, Daniel Sinko, Viktor Szarvas, Ferenc Salamon, Aron Charles Eklund, Zoltan Imre Szallasi, Ferenc Jakab

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    Abstract

    The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years were collected retrospectively from 336 patients with CRC and 118 patients with mCRC. Both in the CRC and the mCRC group overall survival (OS) was significantly worse in patients who had elevated platelet count (hazard ratio [HR] = 2.2, p <0.001 and HR = 2.9, p = 0.018, respectively). Multivariate analysis indicated that elevated platelet count was an independent prognostic factor of CRC (HR = 1.7, p = 0.035) and mCRC (HR = 3.1, p = 0.017). Disease-free survival (DFS) was significantly worse in patients with elevated platelet count in the CRC group (HR = 2.0, p = 0.011). In the multivariate analysis the PLR was not a prognostic factor in either of the two cohorts (HR = 0.92, p <0.001 and HR = 0.89, p = 0.789, respectively). The platelet count is a valuable prognostic marker for the survival in patients both with CRC and mCRC while the PLR is not prognostic in either group.
    Original languageEnglish
    JournalThrombosis and Haemostasis
    Volume111
    Issue number3
    Pages (from-to)483-490
    Number of pages8
    ISSN0340-6245
    DOIs
    Publication statusPublished - 2014

    Cite this

    Baranyai, Z., Krzystanek, M., Josa, V., Dede, K., Ágoston, E., Szasz, A. M., Sinko, D., Szarvas, V., Salamon, F., Eklund, A. C., Szallasi, Z. I., & Jakab, F. (2014). The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer. Thrombosis and Haemostasis, 111(3), 483-490. https://doi.org/10.1160/TH13-08-0632