The Chemistry of Griseofulvin

Asger Bjørn Petersen, Mads Holger Rønnest, Thomas Ostenfeld Larsen, Mads Hartvig Clausen

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Abstract

Specific synthetic routes are presented in schemes to illustrate the chemistry, and the analogs are presented in a table format to give an accessible overview of the structures. Several patents have been published regarding the properties of griseofulvin and its derivatives including synthesis, formulation, and their medicinal and agricultural applications. The antifungal mode-of-action of griseofulvin has been the subject of considerable research efforts and some debate over the years, a discussion that is still ongoing. Griseofulvin was one of the first antifungal natural products found in filamentous fungi. During the years, this polyketide has been found to be produced by several Ascomycetes including both closely and distantly related species.
Original languageEnglish
JournalChemical Reviews
Volume114
Issue number24
Pages (from-to)12088-12107
Number of pages20
ISSN0009-2665
DOIs
Publication statusPublished - 2014

Keywords

  • CHEMISTRY,
  • NUCLEAR-MAGNETIC-RESONANCE
  • CELL-FREE SYSTEM
  • TOTALSYNTHESE VON GRISEOFULVIN
  • B CARBON ANALOG
  • DL-GRISEOFULVIN
  • STREPTOMYCES-CINEREOCROCATUS
  • CHEMICAL STRUCTURE
  • CANCER-CELLS
  • IN-VITRO
  • MICROBIAL TRANSFORMATION
  • Ketones
  • Anti-fungal
  • Filamentous fungi
  • Mode of action
  • Natural products
  • Polyketides
  • Research efforts
  • Synthetic routes
  • Fungi

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