The chemical heritage of Aspergillus flavus in A. oryzae RIB 40

Christian Rank, Marie Louise Klejnstrup, Lene Maj Petersen, Jens Christian Frisvad, Thomas Ostenfeld Larsen

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    Abstract

    Aspergillus oryzae is a very important species in biotechnology and has been used for centuries in traditional Asian fermentation. The RIB40 strain is particularly interesting as it was one of the first genome sequenced Aspergilli together with A. flavus, a prominent food and feed contaminant capable of producing aflatoxin. These species can be perceived as ecotypes. We have analyzed A. oryzae RIB40 and found that the chemical potential could be enhanced significantly under certain conditions. Delicate analysis of their metabolic profiles allow for chemical insight on the transcription level with indications to specific genetic changes. Several new metabolites and changes in biosynthetic routes have been found in A. oryzae, indicating subtle changes in the genomic heritage from A. flavus.
    Original languageEnglish
    Publication date2011
    Publication statusPublished - 2011
    Event26th Fungal Genetics Conference - Pacific Grove, CA, United States
    Duration: 15 Mar 201120 Mar 2011
    Conference number: 26
    http://www.fgsc.net/26thFGC/
    http://www.fgsc.net/26thFGC/

    Conference

    Conference26th Fungal Genetics Conference
    Number26
    CountryUnited States
    CityPacific Grove, CA
    Period15/03/201120/03/2011
    Internet address

    Bibliographical note

    Abstract of poster presentation

    Cite this

    Rank, C., Klejnstrup, M. L., Petersen, L. M., Frisvad, J. C., & Larsen, T. O. (2011). The chemical heritage of Aspergillus flavus in A. oryzae RIB 40. Abstract from 26th Fungal Genetics Conference, Pacific Grove, CA, United States. http://www.fgsc.net/26thFGC/