The cereal pathogen Fusarium pseudograminearum produces a new class of active cytokinins during infection

Jens Laurids Sørensen, Aurelie H. Benfield, Rasmus Dam Wollenberg, Klaus Westphal, Reinhard Wimmer, Mikkel Rank Nielsen, Kristian Fog Nielsen, Jason Carere, Lorenzo Covarelli, Giovanni Beccari, Jonathan Powell, Takafumi Yamashino, Herbert Kogler, Teis Esben Sondergaard, Donald Max Gardiner*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

The fungal pathogen Fusarium pseudograminearum causes important diseases of wheat and barley. During a survey of secondary metabolites produced by this fungus, a novel class of cytokinins, herein termed Fusarium cytokinins, was discovered. Cytokinins are known for their growth promoting and anti-senescence activities and the production of a cytokinin mimic by what was once considered a necrotrophic pathogen that promotes cell death and senescence challenges the simple view that this pathogen invades its hosts by employing a barrage of lytic enzymes and toxins. Through genome mining, a gene cluster in the F. pseudograminearum genome for the production of Fusarium cytokinins was identified and the biosynthetic pathway established using gene knockouts. The Fusarium cytokinins could activate plant cytokinin signalling, demonstrating their genuine hormone mimicry. In planta analysis of the transcriptional response to one Fusarium cytokinin suggests extensive reprogramming of the host environment by these molecules, possibly through crosstalk with defence hormone signalling pathways.
Original languageEnglish
JournalMolecular Plant Pathology
Volume19
Issue number5
Pages (from-to)1140-1154
ISSN1464-6722
DOIs
Publication statusPublished - 2018

Keywords

  • Fusarium
  • Fusarium crown rot
  • Fusarium graminearum
  • Fusarium pseudograminearum
  • Cytokinin
  • Phytohormones
  • Secondary metabolites

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