The cellular impact of glycoengineering

Nathan E. Lewis; Austin W. T. Chiang; Bokan Bao; Curtis Kuo; Benjamin Kellman; Anne Richelle; Albert Liang; Johnny Arnsdorf; Zulfiya Sukhova; Patrice Ménard; Anders H. Hansen; Zhang Yang; Hiren Joshi; Henrik Clausen; Bjorn G. Voldborg

doi:10.1093/glycob/cwy088

The cellular impact of glycoengineering

Nathan E. Lewis
, Austin W. T. Chiang
, Bokan Bao
, Curtis Kuo
, Benjamin Kellman
, Anne Richelle
, Albert Liang
, Johnny Arnsdorf
, Zulfiya Sukhova
, Patrice Ménard
, Anders H. Hansen
, Zhang Yang
, Hiren Joshi
, Henrik Clausen
, Bjorn G. Voldborg

Novo Nordisk Foundation Center for Biosustainability

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

Protein glycosylation is fundamentally important to most biological processes and it is often important to regulate it in biopharmaceutical development. Thus, substantial efforts have been taken to engineer glycosylation of a variety of biologics. However, the diversity and complexity of glycosylation have made it difﬁcult to control glycosylation and unravel how engineering efforts impact the host cells.

Original language	English
Journal	Glycobiology
Volume	28
Issue number	12
Pages (from-to)	1074-1074
ISSN	0959-6658
DOIs	https://doi.org/10.1093/glycob/cwy088
Publication status	Published - 2018
Event	2018 Annual Meeting of the Society for Glycobiology - Hilton New Orleans Riverside, New Orleans, United States Duration: 5 Nov 2018 → 8 Nov 2018

Conference

Conference	2018 Annual Meeting of the Society for Glycobiology
Location	Hilton New Orleans Riverside
Country/Territory	United States
City	New Orleans
Period	05/11/2018 → 08/11/2018

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title = "The cellular impact of glycoengineering",

abstract = "Protein glycosylation is fundamentally important to most biological processes and it is often important to regulate it in biopharmaceutical development. Thus, substantial efforts have been taken to engineer glycosylation of a variety of biologics. However, the diversity and complexity of glycosylation have made it difﬁcult to control glycosylation and unravel how engineering efforts impact the host cells. ",

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AU - Lewis, Nathan E.

AU - Chiang, Austin W. T.

AU - Bao, Bokan

AU - Kuo, Curtis

AU - Kellman, Benjamin

AU - Richelle, Anne

AU - Liang, Albert

AU - Arnsdorf, Johnny

AU - Sukhova, Zulfiya

AU - Ménard, Patrice

AU - Hansen, Anders H.

AU - Yang, Zhang

AU - Joshi, Hiren

AU - Clausen, Henrik

AU - Voldborg, Bjorn G.

PY - 2018

Y1 - 2018

N2 - Protein glycosylation is fundamentally important to most biological processes and it is often important to regulate it in biopharmaceutical development. Thus, substantial efforts have been taken to engineer glycosylation of a variety of biologics. However, the diversity and complexity of glycosylation have made it difﬁcult to control glycosylation and unravel how engineering efforts impact the host cells.

AB - Protein glycosylation is fundamentally important to most biological processes and it is often important to regulate it in biopharmaceutical development. Thus, substantial efforts have been taken to engineer glycosylation of a variety of biologics. However, the diversity and complexity of glycosylation have made it difﬁcult to control glycosylation and unravel how engineering efforts impact the host cells.

U2 - 10.1093/glycob/cwy088

DO - 10.1093/glycob/cwy088

M3 - Conference abstract in journal

SN - 0959-6658

VL - 28

SP - 1074

EP - 1074

JO - Glycobiology

JF - Glycobiology

IS - 12

T2 - 2018 Annual Meeting of the Society for Glycobiology

Y2 - 5 November 2018 through 8 November 2018

ER -

The cellular impact of glycoengineering

Abstract

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