TY - JOUR
T1 - The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1
T2 - An IMI DIRECT Study
AU - Eriksen, Rebeca
AU - White, Margaret C.
AU - Dawed, Adem Y.
AU - Perez, Isabel Garcia
AU - Posma, Joram M.
AU - Haid, Mark
AU - Sharma, Sapna
AU - Prehn, Cornelia
AU - Thomas, E. Louise
AU - Koivula, Robert W.
AU - Bizzotto, Roberto
AU - Mari, Andrea
AU - Giordano, Giuseppe N.
AU - Pavo, Imre
AU - Schwenk, Jochen M.
AU - De Masi, Federico
AU - Tsirigos, Konstantinos D.
AU - Brunak, Søren
AU - Viñuela, Ana
AU - Mahajan, Anubha
AU - McDonald, Timothy J.
AU - Kokkola, Tarja
AU - Rutters, Femke
AU - Beulens, Joline
AU - Muilwijk, Mirthe
AU - Blom, Marieke
AU - Elders, Petra
AU - Hansen, Tue H.
AU - Fernandez-Tajes, Juan
AU - Jones, Angus
AU - Jennison, Chris
AU - Walker, Mark
AU - McCarthy, Mark I.
AU - Pedersen, Oluf
AU - Ruetten, Hartmut
AU - Forgie, Ian
AU - Holst, Jens J.
AU - Thomsen, Henrik S.
AU - Ridderstråle, Martin
AU - Bell, Jimmy D.
AU - Adamski, Jerzy
AU - Franks, Paul W.
AU - Hansen, Torben
AU - Holmes, Elaine
AU - Frost, Gary
AU - Pearson, Ewan R.
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2024
Y1 - 2024
N2 - Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D. Results: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes. Conclusion: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
AB - Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D. Results: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes. Conclusion: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
KW - Cardiometabolic markers
KW - Diet
KW - GLP-1
KW - Incretin
KW - Insulin resistance
KW - Liver fat
KW - Nutrition
KW - Obesity
KW - Prediabetes
KW - Type 2 diabetes
U2 - 10.1210/clinem/dgae119
DO - 10.1210/clinem/dgae119
M3 - Journal article
C2 - 38686701
AN - SCOPUS:85201230805
SN - 0021-972X
VL - 109
SP - e1697-e1707
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -