Microneedles are microstructured needle-shaped structures that may be used for transdermal delivery of vaccines and pharmacologic agents, including antibacterial agents for treatment of skin infections. In this study, a combination of visible light dynamic mask micro-stereolithography and micromolding was used to prepare microneedle arrays out of a biodegradable acid anhydride copolymer. Nanoindentation was performed to obtain Young's modulus and hardness data for the acid anhydride copolymer material. Agar plating studies were used to evaluate the in vitro performance of acid anhydride copolymer microneedle arrays against several microorganisms, including Candida albicans, Bacilus subtilis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Large zones of inhibited growth were observed for Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, and Bacilus subtilis. The performance of acid anhydride copolymer microneedle arrays created using visible light dynamic mask micro-stereolithography-micromolding against several bacteria indicates that these devices may be appropriate for treating skin infections associated with several types of bacteria.
|Journal||Journal of Investigative Dermatology|
|Issue number||Suppl. 1|
|Publication status||Published - 2012|
Boehm, R. D., Miller, PR., Petersen, R. S., Shah, A., Stafslien, S., Daniels, J., & Narayan, R. J. (2012). The antibacterial properties of acid anhydride copolymer microneedles. Journal of Investigative Dermatology, 132(Suppl. 1), S108. .