Terahertz time-domain spectroscopy and imaging of artificial RNA

Bernd M. Fischer; Matthias Hoffmann; Hanspeter Helm; Rafal Wilk; Frank Rutz; Thomas Kleine-Ostermann; Martin Koch; Peter Uhd Jepsen

doi:10.1364/OPEX.13.005205

Terahertz time-domain spectroscopy and imaging of artificial RNA

Bernd M. Fischer, Matthias Hoffmann, Hanspeter Helm, Rafal Wilk, Frank Rutz, Thomas Kleine-Ostermann, Martin Koch, Peter Uhd Jepsen

Department of Photonics Engineering

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra.

Original language	English
Journal	Optics Express
Volume	13
Issue number	14
Pages (from-to)	5205-1215
ISSN	1094-4087
DOIs	https://doi.org/10.1364/OPEX.13.005205
Publication status	Published - 2005

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10.1364/OPEX.13.005205

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title = "Terahertz time-domain spectroscopy and imaging of artificial RNA",

abstract = "We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra.",

author = "Fischer, {Bernd M.} and Matthias Hoffmann and Hanspeter Helm and Rafal Wilk and Frank Rutz and Thomas Kleine-Ostermann and Martin Koch and Jepsen, {Peter Uhd}",

year = "2005",

doi = "10.1364/OPEX.13.005205",

language = "English",

volume = "13",

pages = "5205--1215",

journal = "Optics Express",

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publisher = "The Optical Society",

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TY - JOUR

T1 - Terahertz time-domain spectroscopy and imaging of artificial RNA

AU - Fischer, Bernd M.

AU - Hoffmann, Matthias

AU - Helm, Hanspeter

AU - Wilk, Rafal

AU - Rutz, Frank

AU - Kleine-Ostermann, Thomas

AU - Koch, Martin

AU - Jepsen, Peter Uhd

PY - 2005

Y1 - 2005

N2 - We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra.

AB - We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra.

U2 - 10.1364/OPEX.13.005205

DO - 10.1364/OPEX.13.005205

M3 - Journal article

VL - 13

SP - 5205

EP - 1215

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 14

ER -