Targeting the transferrin receptor for brain drug delivery

Kasper Bendix Johnsen, Annette Burkhart, Louiza Bohn Thomsen, Thomas Lars Andresen, Torben Moos

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the entrance of most molecules present in the systemic circulation, especially large molecule drugs and nanomedicines. To overcome this obstacle, targeting strategies binding to nutrient receptors present at the luminal membrane of the BBB are frequently employed. Amongst the numerous potential targets at the BBB, the transferrin receptor (TfR) remains the most common target used to ensure sufficient drug delivery to the brain. In this review, we provide a full account on the use of the TfR as a target for brain drug delivery by describing the function of the TfR in the BBB, the historical background of its use in drug delivery, and the most recent evidence suggesting TfR-targeted medicines to be efficient for brain drug delivery with a clear clinical potential.
Original languageEnglish
Article number101665
JournalProgress in Neurobiology
Volume181
Number of pages30
ISSN0301-0082
DOIs
Publication statusPublished - 2019

Keywords

  • Antibody
  • Brain drug delivery
  • Nanoparticle
  • Transcytosis
  • Transferrin receptor

Cite this

Johnsen, Kasper Bendix ; Burkhart, Annette ; Thomsen, Louiza Bohn ; Andresen, Thomas Lars ; Moos, Torben. / Targeting the transferrin receptor for brain drug delivery. In: Progress in Neurobiology. 2019 ; Vol. 181.
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Targeting the transferrin receptor for brain drug delivery. / Johnsen, Kasper Bendix; Burkhart, Annette; Thomsen, Louiza Bohn; Andresen, Thomas Lars; Moos, Torben.

In: Progress in Neurobiology, Vol. 181, 101665, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

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AU - Johnsen, Kasper Bendix

AU - Burkhart, Annette

AU - Thomsen, Louiza Bohn

AU - Andresen, Thomas Lars

AU - Moos, Torben

PY - 2019

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AB - Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the entrance of most molecules present in the systemic circulation, especially large molecule drugs and nanomedicines. To overcome this obstacle, targeting strategies binding to nutrient receptors present at the luminal membrane of the BBB are frequently employed. Amongst the numerous potential targets at the BBB, the transferrin receptor (TfR) remains the most common target used to ensure sufficient drug delivery to the brain. In this review, we provide a full account on the use of the TfR as a target for brain drug delivery by describing the function of the TfR in the BBB, the historical background of its use in drug delivery, and the most recent evidence suggesting TfR-targeted medicines to be efficient for brain drug delivery with a clear clinical potential.

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KW - Brain drug delivery

KW - Nanoparticle

KW - Transcytosis

KW - Transferrin receptor

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