Targeted nanoparticles for colorectal cancer

Bruno A. Cisterna, Nazila Kamaly, Won Il Choi, Ali Tavakkoli, Omid C. Farokhzad, Cristian Vilos

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Colorectal cancer (CRC) is highly prevalent worldwide, and despite notable progress in treatment still leads to significant morbidity and mortality. The use of nanoparticles as a drug delivery system has become one of the most promising strategies for cancer therapy. Targeted nanoparticles could take advantage of differentially expressed molecules on the surface of tumor cells, providing effective release of cytotoxic drugs. Several efforts have recently reported the use of diverse molecules as ligands on the surface of nanoparticles to interact with the tumor cells, enabling the effective delivery of antitumor agents. Here, we present recent advances in targeted nanoparticles against CRC and discuss the promising use of ligands and cellular targets in potential strategies for the treatment of CRCs.
    Original languageEnglish
    JournalNanomedicine
    Volume11
    Issue number18
    Pages (from-to)2443-2456
    Number of pages14
    ISSN1743-5889
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Cancer therapy
    • Colorectal cancer (CRC)
    • Controlled release
    • Drug delivery
    • Targeted nanoparticles

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