Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Katja E. Grier, Anders H. Hansen, Christina S. Haxvig, Xin Li, Oliver Krigslund, Niels Behrendt, Lars H. Engelholm, Fabio Rossi, Bebiana C. Sousa, Grant J. Harradence, Nicolas Camper, Katrine M. Qvortrup*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

Original languageEnglish
JournalChemical Communications
Volume59
Pages (from-to)7240–7242
ISSN1359-7345
DOIs
Publication statusPublished - 2023

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