Tandem Ring-Closing Metathesis/Isomerization Reactions for the Total Synthesis of Violacein

Mette T. Petersen, Thomas Eiland Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein.
Original languageEnglish
JournalOrganic Letters
Volume15
Issue number8
Pages (from-to)1986-1989
ISSN1523-7060
DOIs
Publication statusPublished - 2013

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