Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

Peng Wu, Michael Åxman Petersen, Rico Petersen, Thomas Flagstad, Rachel Guilleux, Martin Ohsten Rasmussen, Rémy Morgentin, Thomas Eiland Nielsen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review

489 Downloads (Pure)

Abstract

A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.
Original languageEnglish
JournalRSC Advances
Volume2016
Issue number6
Pages (from-to)46654-46657
ISSN2046-2069
DOIs
Publication statusPublished - 2016

Bibliographical note

This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

Cite this

Wu, P., Petersen, M. Å., Petersen, R., Flagstad, T., Guilleux, R., Ohsten Rasmussen, M., Morgentin, R., Nielsen, T. E., & Clausen, M. H. (2016). Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries. RSC Advances, 2016(6), 46654-46657. https://doi.org/10.1039/C6RA08786H