A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.
Bibliographical noteThis article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wu, P., Petersen, M. Å., Petersen, R., Flagstad, T., Guilleux, R., Ohsten Rasmussen, M., Morgentin, R., Nielsen, T. E., & Clausen, M. H. (2016). Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries. RSC Advances, 2016(6), 46654-46657. https://doi.org/10.1039/C6RA08786H