Taichunins E-T, Isopimarane Diterpenes and a 20-nor-Isopimarane, from Aspergillus taichungensis (IBT 19404): Structures and Inhibitory Effects on RANKL-Induced Formation of Multinuclear Osteoclasts

Ahmed H. H. El-Desoky, Natsumi Inada, Yuka Maeyama, Hikaru Kato, Yuki Hitora, Momona Sebe, Mika Nagaki, Aika Kai, Keisuke Eguchi, Tomoaki Inazumi, Yukihiko Sugimoto, Jens C. Frisvad, Robert M. Williams, Sachiko Tsukamoto*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Fifteen new isopimarane-type diterpenes, taichunins E-S (1-15), and a new 20-nor-isopimarane, taichunin T (16), together with four known compounds were isolated from Aspergillus taichungensis (IBT 19404). The structures of these new compounds were determined by NMR and mass spectroscopy, and their absolute configurations were analyzed by NOESY and TDDFT calculations of ECD spectra. Taichunins G, K, and N (3, 7, and 10) completely inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts in RAW264 cells at 5 μM, with 3 showing 92% inhibition at a concentration of 0.2 μM.
Original languageEnglish
JournalJournal of Natural Products
Volume84
Issue number9
Pages (from-to)2475-2485
Number of pages11
ISSN0163-3864
DOIs
Publication statusPublished - 2021

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