Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato; Momona Sebe; Mika Nagaki; Keisuke Eguchi; Ippei Kagiyama; Yuki Hitora; Jens Christian Frisvad; Robert M. Williams; Sachiko Tsukamoto

doi:10.1021/acs.jnatprod.8b01032

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato
, Momona Sebe
, Mika Nagaki
, Keisuke Eguchi
, Ippei Kagiyama
, Yuki Hitora
, Jens Christian Frisvad
, Robert M. Williams
, Sachiko Tsukamoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC₅₀ value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

Original language	English
Journal	Journal of Natural Products
Volume	82
Issue number	5
Pages (from-to)	1377-1381
Number of pages	5
ISSN	0163-3864
DOIs	https://doi.org/10.1021/acs.jnatprod.8b01032
Publication status	Published - 2019

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title = "Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)",

abstract = "Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.",

author = "Hikaru Kato and Momona Sebe and Mika Nagaki and Keisuke Eguchi and Ippei Kagiyama and Yuki Hitora and Frisvad, \{Jens Christian\} and Williams, \{Robert M.\} and Sachiko Tsukamoto",

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language = "English",

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AU - Kato, Hikaru

AU - Sebe, Momona

AU - Nagaki, Mika

AU - Eguchi, Keisuke

AU - Kagiyama, Ippei

AU - Hitora, Yuki

AU - Frisvad, Jens Christian

AU - Williams, Robert M.

AU - Tsukamoto, Sachiko

PY - 2019

Y1 - 2019

N2 - Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

AB - Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

U2 - 10.1021/acs.jnatprod.8b01032

DO - 10.1021/acs.jnatprod.8b01032

M3 - Journal article

C2 - 30995043

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EP - 1381

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

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