Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato; Momona Sebe; Mika Nagaki; Keisuke Eguchi; Ippei Kagiyama; Yuki Hitora; Jens Christian Frisvad; Robert M. Williams; Sachiko Tsukamoto

doi:10.1021/acs.jnatprod.8b01032

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato, Momona Sebe, Mika Nagaki, Keisuke Eguchi, Ippei Kagiyama, Yuki Hitora, Jens Christian Frisvad, Robert M. Williams, Sachiko Tsukamoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC₅₀ value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

Original language	English
Journal	Journal of Natural Products
Volume	82
Issue number	5
Pages (from-to)	1377-1381
Number of pages	5
ISSN	0163-3864
DOIs	https://doi.org/10.1021/acs.jnatprod.8b01032
Publication status	Published - 2019

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10.1021/acs.jnatprod.8b01032

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title = "Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)",

abstract = "Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.",

author = "Hikaru Kato and Momona Sebe and Mika Nagaki and Keisuke Eguchi and Ippei Kagiyama and Yuki Hitora and Frisvad, {Jens Christian} and Williams, {Robert M.} and Sachiko Tsukamoto",

year = "2019",

doi = "10.1021/acs.jnatprod.8b01032",

language = "English",

volume = "82",

pages = "1377--1381",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "5",

}

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404). / Kato, Hikaru; Sebe, Momona; Nagaki, Mika; Eguchi, Keisuke; Kagiyama, Ippei; Hitora, Yuki; Frisvad, Jens Christian; Williams, Robert M.; Tsukamoto, Sachiko.

In: Journal of Natural Products, Vol. 82, No. 5, 2019, p. 1377-1381.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

AU - Kato, Hikaru

AU - Sebe, Momona

AU - Nagaki, Mika

AU - Eguchi, Keisuke

AU - Kagiyama, Ippei

AU - Hitora, Yuki

AU - Frisvad, Jens Christian

AU - Williams, Robert M.

AU - Tsukamoto, Sachiko

PY - 2019

Y1 - 2019

N2 - Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

AB - Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

U2 - 10.1021/acs.jnatprod.8b01032

DO - 10.1021/acs.jnatprod.8b01032

M3 - Journal article

C2 - 30995043

VL - 82

SP - 1377

EP - 1381

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

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