Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato, Momona Sebe, Mika Nagaki, Keisuke Eguchi, Ippei Kagiyama, Yuki Hitora, Jens Christian Frisvad, Robert M. Williams, Sachiko Tsukamoto*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.
Original languageEnglish
JournalJournal of Natural Products
Volume82
Issue number5
Pages (from-to)1377-1381
Number of pages5
ISSN0163-3864
DOIs
Publication statusPublished - 2019

Cite this

Kato, H., Sebe, M., Nagaki, M., Eguchi, K., Kagiyama, I., Hitora, Y., ... Tsukamoto, S. (2019). Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404). Journal of Natural Products, 82(5), 1377-1381. https://doi.org/10.1021/acs.jnatprod.8b01032
Kato, Hikaru ; Sebe, Momona ; Nagaki, Mika ; Eguchi, Keisuke ; Kagiyama, Ippei ; Hitora, Yuki ; Frisvad, Jens Christian ; Williams, Robert M. ; Tsukamoto, Sachiko. / Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404). In: Journal of Natural Products. 2019 ; Vol. 82, No. 5. pp. 1377-1381.
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title = "Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)",
abstract = "Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.",
author = "Hikaru Kato and Momona Sebe and Mika Nagaki and Keisuke Eguchi and Ippei Kagiyama and Yuki Hitora and Frisvad, {Jens Christian} and Williams, {Robert M.} and Sachiko Tsukamoto",
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Kato, H, Sebe, M, Nagaki, M, Eguchi, K, Kagiyama, I, Hitora, Y, Frisvad, JC, Williams, RM & Tsukamoto, S 2019, 'Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)', Journal of Natural Products, vol. 82, no. 5, pp. 1377-1381. https://doi.org/10.1021/acs.jnatprod.8b01032

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404). / Kato, Hikaru; Sebe, Momona; Nagaki, Mika; Eguchi, Keisuke; Kagiyama, Ippei; Hitora, Yuki; Frisvad, Jens Christian; Williams, Robert M.; Tsukamoto, Sachiko.

In: Journal of Natural Products, Vol. 82, No. 5, 2019, p. 1377-1381.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

AU - Kato, Hikaru

AU - Sebe, Momona

AU - Nagaki, Mika

AU - Eguchi, Keisuke

AU - Kagiyama, Ippei

AU - Hitora, Yuki

AU - Frisvad, Jens Christian

AU - Williams, Robert M.

AU - Tsukamoto, Sachiko

PY - 2019

Y1 - 2019

N2 - Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

AB - Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

U2 - 10.1021/acs.jnatprod.8b01032

DO - 10.1021/acs.jnatprod.8b01032

M3 - Journal article

VL - 82

SP - 1377

EP - 1381

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -