Tackling Cancer with Yeast-Based Technologies

Raphael Ferreira, Angelo Limeta, Jens Nielsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The ability to precisely engineer yeast, coupled with its genetic and metabolic similarity to tumor cells, has enabled researchers to use this organism in cancer research. Here we review advances that leveraged yeast as a model organism for studying cancer biology, including the investigation of tumorigenic mechanisms, development of advanced technologies for drug discovery, production of anticancer drugs on an industrial scale, and delivering the next generation of immunotherapies.
Original languageEnglish
JournalTrends in Biotechnology
Volume37
Issue number6
Pages (from-to)592-603
Number of pages12
ISSN0167-7799
DOIs
Publication statusPublished - 2019

Keywords

  • CRISPR
  • SGA
  • Cancer vaccines
  • Humanized antibody
  • Immunotherapy
  • Metabolic engineering

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