T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes

Ling Ding, Roland Pfoh, Stephan Ruehl, Song Qin, Hartmut Laatsch

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC50 of 6.7 mu g/mL.
Original languageEnglish
JournalJournal of Natural Products
Volume72
Issue number1
Pages (from-to)99-101
Number of pages3
ISSN0163-3864
DOIs
Publication statusPublished - 2009
Externally publishedYes

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