T Cell Epitope Predictions

Bjoern Peters, Morten Nielsen, Alessandro Sette

Research output: Contribution to journalJournal articleResearchpeer-review


Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity, transplantation, and cancer. The specific T cell epitopes recognized in an individual are determined by genetic factors such as the MHC molecules the individual expresses, in parallel to the individual's environmental exposure history. The complexity and importance of T cell epitope mapping has motivated the development of computational approaches that predict what T cell epitopes are likely to be recognized in a given individual or in a broader population. Such predictions guide experimental epitope mapping studies and enable computational analysis of the immunogenic potential of a given protein sequence region. Expected final online publication date for the Annual Review of Immunology, Volume 38 is April 26, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Original languageEnglish
JournalAnnual Review of Immunology
Issue number1
Pages (from-to)123-145
Publication statusPublished - 2020


  • T cells
  • Benchmarking
  • Databases
  • Immune epitopes
  • Machine learning

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