T Cell Epitope Prediction and Its Application to Immunotherapy

Anna Lisa Schaap-Johansen, Milena Vujović, Annie Borch, Sine Reker Hadrup, Paolo Marcatili*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aimed at identifying neoepitopes, i.e. cancer-specific peptides and their potential for use in immunotherapy for cancer treatment. This review will cover how these tools work, what kind of data they use, as well as pros and cons in their respective applications.

Original languageEnglish
Article number712488
JournalFrontiers in Immunology
Number of pages11
Publication statusPublished - 2021


  • Epitope prediction
  • Neoantigens
  • Neoepitope prediction
  • T cell
  • T cell receptor
  • TCR


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