T-2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation: A novel idea for full-brain mapping of oxygen saturation

Thomas Alderliesten, Jill B. De Vis, Petra M. A. Lemmers, Frank van Bel, Manon J. N. L. Benders, Jeroen Hendrikse, Esben Thade Petersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background and aim: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The "modified T-2-prepared Blood Imaging of Oxygen Saturation" (T-2-BIOS) MR sequence provides a step towards full brain SO2 measurement.Materials andmethods: Tissue SO2, and venous SO2 (SvO2) were obtained simultaneously by T-2-BIOS during a respiratory challenge in ten healthy volunteers. These twomeasureswere compared to SO2 that was obtained by a single probe MR-compatible NIRS setup, and to cerebral blood flow and venous SO2 that were obtained by arterial spin labelling and T-2-TRIR, respectively.Results: SO2-T2-BIOS and SO2-NIRS had a mean bias of -4.0% (95% CI-21.3% to 13.3%). SvO2-T2-BIOS correlated with SO2-NIRS (R-2= 0.41, p= 0.002) and SvO2-T2-TRIR (R-2= 0.87, p= 0.002). In addition, SO2-NIRS correlated with SvO2-T2-TRIR (R-2 = 0.85, p = 0.003) Frontal cerebral blood flow correlated with SO2-T2-BIOS (R-2 = 0.21, p = 0.04), but was not significant in relation to SO2-NIRS.Discussion/conclusion: Full brain SO2 assessment by any technique may help validating NIRS and may prove useful in guiding the clinical management of patient populations with cerebral injury following hypoxic-ischaemic events. The agreement between NIRS and T-2-BIOS provides confidence in measuring cerebral SO2 by either technique. As it stands now, the T-2-BIOS represents a novel idea and future work will focus on improvements to make it a reliable tool for SO2 assessment. (C) 2016 Elsevier Inc. All rights reserved.
Original languageEnglish
JournalNeuroImage
Volume139
Pages (from-to)65-73
ISSN1053-8119
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Neurology
  • Cognitive Neuroscience
  • Adults
  • Cerebral oxygenation
  • Near-Infrared Spectroscopy
  • Respiratory challenge
  • NEUROSCIENCES
  • NEUROIMAGING
  • RADIOLOGY,
  • NEAR-INFRARED SPECTROSCOPY
  • CEREBRAL BLOOD-VOLUME
  • POSITRON-EMISSION-TOMOGRAPHY
  • EXTRACTION FRACTION
  • TISSUE OXYGENATION
  • NONINVASIVE MEASUREMENT
  • OPTICAL-PROPERTIES
  • CALIBRATED MRI
  • METABOLIC-RATE
  • FOCAL CHANGES
  • Nervous system - Physiology and biochemistry
  • Animals, Chordates, Humans, Mammals, Primates, Vertebrates
  • cerebral blood flow
  • frontal cerebral blood flow
  • respiratory challenge
  • cerebral oxygenation saturation

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