@inbook{7271e8bb58ed44d192397aa7a907c8f1,
title = "Systems-Wide Analyses of Immune Programming of Regulatory T Cells in Early Life Providing Lifelong Protection from Diseases",
abstract = "Regulatory T cells (Tregs) are fundamental for lifelong protection against a wide range of noncommunicable diseases in which the immune system contributes to undesirable host-destructive processes, such as autoimmune diseases, asthma, and allergies. Based on epidemiological and experimental studies, it has become evident that genetic, cultural, social, pregnancy-, and birth-related predisposition influence the induction of tolerance in early life to self-antigens and harmless non-self-antigens, but specific mechanisms driving the influence have remained elusive. We here review and discuss recently generated knowledge from systems-wide studies combined with omics technologies which are starting to untangle the network of environmental factors (including birth mode, breastfeeding, bacteria, metabolites, and time window) influencing generation of Tregs. Additionally, we present data from studies demonstrating how multi-omics and epigenetic studies may bridge environmental factors and autoimmune diseases and address how these findings point at new therapeutic avenues for treatment or ways to prevent disease development via modulation of Tregs.",
keywords = "Systems immunology, Systems biology, Host-microbe interactions, Early-life immune interprinting, Regulatory T cells, Tolerance, Window of opportunity, Epigenietics, Noncommunicable diseases, Multi-omics technologies",
author = "Dehli, {Rasmus Ibsen} and Susanne Brix",
year = "2024",
doi = "10.1007/978-3-031-62178-9_15",
language = "English",
isbn = "978-3-031-62177-2",
series = "RNA Technologies",
publisher = "Springer",
pages = "329--351",
editor = "Jan Barcizewski",
booktitle = "Systems Biology II",
}