Systems glycobiology for glycoengineering

Philipp N. Spahn, Nathan Lewis

    Research output: Contribution to journalJournal articleResearchpeer-review


    Glycosylation serves essential functions on many proteins produced in biopharmaceutical manufacturing, making it mandatory to thoroughly consider its biogenesis during the production process. Glycoengineering efforts involve the rational design of glycosylation through adjustments in culturing conditions or genetic modifications. Computational models have been developed to aid this process, aiming to offer cheaper and faster alternatives to costly screening strategies. Recently, these models have been successfully utilized to predict glycosylation of products of industrial relevance. Furthermore, systems-level analyses of glycan diversity are elucidating deeper insights into the mechanisms underlying glycosylation. As computational models of glycosylation continue to be expanded, refined, and leveraged for detailed analysis of glycomics data, they will become invaluable resources for cell line development and glycoengineering.
    Original languageEnglish
    JournalCurrent Opinion in Biotechnology
    Pages (from-to)218-224
    Number of pages7
    Publication statusPublished - 2014


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