Systems biology solutions for biochemical production challenges

Anne Sofie Lærke Hansen; Rebecca M Lennen; Nikolaus Sonnenschein; Markus Herrgard

doi:10.1016/j.copbio.2016.11.018

Systems biology solutions for biochemical production challenges

Anne Sofie Lærke Hansen
, Rebecca M Lennen
, Nikolaus Sonnenschein
, Markus Herrgard

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals.

Original language	English
Journal	Current Opinion in Biotechnology
Volume	45
Pages (from-to)	85-91
ISSN	0958-1669
DOIs	https://doi.org/10.1016/j.copbio.2016.11.018
Publication status	Published - 2017

Bibliographical note

This article is available under the terms of the Creative Commons Attribution License (CC BY).
You may copy and distribute the article, create extracts, abstracts and new works from the article, alter and revise the article, text or data mine the article and otherwise reuse the article commercially (including reuse and/or resale of the article) without permission from Elsevier. You must give appropriate credit to the original work, together with a link to the formal publication through the relevant DOI and a link to the Creative Commons user license above. You must indicate if any changes are made but not in any way that suggests the licensor endorses you or your use of the work.

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UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

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10.1016/j.copbio.2016.11.018

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DD-DeCaF: Bioinformatics Services for Data-Driven Design of Cell Factories and Communities
Herrgard, M. (Project Coordinator), Sonnenschein, N. (Project Coordinator), Kutuzova, S. (Project Participant), Redestig, N. H. (Project Participant), Beber, M. E. (Project Participant), Dannaher, D. (Project Participant), Lopez Benito, A. (Project Participant), Kaafarani, A. (Project Participant), Lieven, C. (Project Participant), Lohmann, R. (Project Manager), Rasmussen, B. K. (Project Manager), Kjiproski, D. (Project Manager) & Knudsen, E. B. (Project Manager)
Horizon 2020 Framework Programme
01/03/2016 → 29/02/2020
Project: Research

Cite this

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title = "Systems biology solutions for biochemical production challenges",

abstract = "There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals.",

author = "Hansen, \{Anne Sofie L{\ae}rke\} and Lennen, \{Rebecca M\} and Nikolaus Sonnenschein and Markus Herrgard",

note = "This article is available under the terms of the Creative Commons Attribution License (CC BY). You may copy and distribute the article, create extracts, abstracts and new works from the article, alter and revise the article, text or data mine the article and otherwise reuse the article commercially (including reuse and/or resale of the article) without permission from Elsevier. You must give appropriate credit to the original work, together with a link to the formal publication through the relevant DOI and a link to the Creative Commons user license above. You must indicate if any changes are made but not in any way that suggests the licensor endorses you or your use of the work. Permission is not required for this type of reuse.",

year = "2017",

doi = "10.1016/j.copbio.2016.11.018",

language = "English",

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journal = "Current Opinion in Biotechnology",

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AU - Sonnenschein, Nikolaus

AU - Herrgard, Markus

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N2 - There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals.

AB - There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals.

U2 - 10.1016/j.copbio.2016.11.018

DO - 10.1016/j.copbio.2016.11.018

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VL - 45

SP - 85

EP - 91

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

ER -

Systems biology solutions for biochemical production challenges

Abstract

Bibliographical note

UN SDGs

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Projects

DD-DeCaF: Bioinformatics Services for Data-Driven Design of Cell Factories and Communities

Cite this