Abstract
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.
| Original language | English |
|---|---|
| Journal | Annual Review of Biochemistry |
| Volume | 86 |
| Pages (from-to) | 245-275 |
| ISSN | 0066-4154 |
| DOIs | |
| Publication status | Published - 2017 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Genome-scale metabolic models
- Metabolic engineering
- Metabolomics
- Proteomics
- Systems medicine
- Transcriptomics
Fingerprint
Dive into the research topics of 'Systems Biology of Metabolism: Annual Review of Biochemistry'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver